caa a22 4500 397574770 CHVBK 20180308164852.0 cr unu---uuuuu 161202e199604 xx s 000 0 eng 10.1093/hmg/5.4.513 doi (NATIONALLICENCE)oxford-10.1093/hmg/5.4.513 A Murine Homologue of the Human Daz Gene Is Autosomal and Expressed only in Male and Female Gonads [Elektronische Daten] [Howard J. Cooke, Muriel Lee, Shona Kerr, Matteo Ruggiu] We have isolated a homologue of the human Y linked DAZ (deleted in azoospermia) gene from mouse. This gene, Dazla (Daz like, autosomal), is autosomal, located on chromosome 17 and apparently single copy. The predicted protein is highly homologous to that encoded by the DAZ gene in the N-terminal regions of the two proteins and this homology is not confined to the RNA binding domain. Analysis of its expression pattern by reverse transcription PCR shows that the transcript is only detectable in male and female gonads and that testes lacking germ cells do not contain detectable amounts of transcript. We have been unable to detect a Y-linked DAZhomologue in mouse and our results point to the possibility of a role for autosomal RNA binding proteins in mammalian gametogenesis. © 1996 Oxford University Press Cooke Howard J. Medical Research Council Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK aut Lee Muriel Medical Research Council Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK aut Kerr Shona Medical Research Council Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK aut Ruggiu Matteo Medical Research Council Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK aut Human Molecular Genetics Oxford University Press 5/4(1996-04), 513-516 0964-6906 5:4<513 1996 5 hmg https://doi.org/10.1093/hmg/5.4.513 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/hmg/5.4.513 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cooke Howard J. Medical Research Council Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK aut NATIONALLICENCE 700 1- Lee Muriel Medical Research Council Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK aut NATIONALLICENCE 700 1- Kerr Shona Medical Research Council Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK aut NATIONALLICENCE 700 1- Ruggiu Matteo Medical Research Council Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK aut NATIONALLICENCE 773 0- Human Molecular Genetics Oxford University Press 5/4(1996-04), 513-516 0964-6906 5:4<513 1996 5 hmg Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford