caa a22 4500 397574835 CHVBK 20180308164852.0 cr unu---uuuuu 161202e199607 xx s 000 0 eng 10.1093/hmg/5.7.1071 doi (NATIONALLICENCE)oxford-10.1093/hmg/5.7.1071 Saturation Multipoint Linkage Mapping of Chromosome 6q in Type 1 Diabetes [Elektronische Daten] [June L. Davies, Francesco Cucca, Juliet V. Goy, Zeinat A. A. Atta, Marilyn E. Merriman, Amanda Wilson, Anthony H. Barnett, Stephen C. Bain, John A. Todd] Linkage analysis of type 1 diabetes sib pair families (n = 334) has suggested two separate regions of human chromosome 6q are linked to disease (designated IDDM5 and IDDM8). To test if these are false positive results, all available sib pair families (n = 429) were typed using a 92% informative map of chromosome 6q and multipoint analysis. The two regions still showed positive evidence of linkage, most notably the proterminal region, 6q27, corresponding to IDDM8 (MLS = 2.57, p = 0.0006; λs = 1.17). In addition, some evidence of transmission disequilibrium was seen with marker a046xa9 (IDDM5). © 1996 Oxford University Press Davies June L. Wellcome Trust Centre for Human Genetics, Nuffield Department of Surgery, University of Oxford, Windmill Road, Headington, Oxford OX3 7BN, UK aut Cucca Francesco Wellcome Trust Centre for Human Genetics, Nuffield Department of Surgery, University of Oxford, Windmill Road, Headington, Oxford OX3 7BN, UK aut Goy Juliet V. Wellcome Trust Centre for Human Genetics, Nuffield Department of Surgery, University of Oxford, Windmill Road, Headington, Oxford OX3 7BN, UK aut Atta Zeinat A. A. Wellcome Trust Centre for Human Genetics, Nuffield Department of Surgery, University of Oxford, Windmill Road, Headington, Oxford OX3 7BN, UK aut Merriman Marilyn E. Wellcome Trust Centre for Human Genetics, Nuffield Department of Surgery, University of Oxford, Windmill Road, Headington, Oxford OX3 7BN, UK aut Wilson Amanda Wellcome Trust Centre for Human Genetics, Nuffield Department of Surgery, University of Oxford, Windmill Road, Headington, Oxford OX3 7BN, UK aut Barnett Anthony H. Department of Medicine/Diabetes/Endocrinology, University of Birmingham, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham B9 5SS, UK aut Bain Stephen C. Department of Medicine/Diabetes/Endocrinology, University of Birmingham, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham B9 5SS, UK aut Todd John A. Wellcome Trust Centre for Human Genetics, Nuffield Department of Surgery, University of Oxford, Windmill Road, Headington, Oxford OX3 7BN, UK aut Human Molecular Genetics Oxford University Press 5/7(1996-07), 1071-1074 0964-6906 5:7<1071 1996 5 hmg https://doi.org/10.1093/hmg/5.7.1071 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/hmg/5.7.1071 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Davies June L. Wellcome Trust Centre for Human Genetics, Nuffield Department of Surgery, University of Oxford, Windmill Road, Headington, Oxford OX3 7BN, UK aut NATIONALLICENCE 700 1- Cucca Francesco Wellcome Trust Centre for Human Genetics, Nuffield Department of Surgery, University of Oxford, Windmill Road, Headington, Oxford OX3 7BN, UK aut NATIONALLICENCE 700 1- Goy Juliet V. Wellcome Trust Centre for Human Genetics, Nuffield Department of Surgery, University of Oxford, Windmill Road, Headington, Oxford OX3 7BN, UK aut NATIONALLICENCE 700 1- Atta Zeinat A. A. Wellcome Trust Centre for Human Genetics, Nuffield Department of Surgery, University of Oxford, Windmill Road, Headington, Oxford OX3 7BN, UK aut NATIONALLICENCE 700 1- Merriman Marilyn E. Wellcome Trust Centre for Human Genetics, Nuffield Department of Surgery, University of Oxford, Windmill Road, Headington, Oxford OX3 7BN, UK aut NATIONALLICENCE 700 1- Wilson Amanda Wellcome Trust Centre for Human Genetics, Nuffield Department of Surgery, University of Oxford, Windmill Road, Headington, Oxford OX3 7BN, UK aut NATIONALLICENCE 700 1- Barnett Anthony H. Department of Medicine/Diabetes/Endocrinology, University of Birmingham, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham B9 5SS, UK aut NATIONALLICENCE 700 1- Bain Stephen C. Department of Medicine/Diabetes/Endocrinology, University of Birmingham, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham B9 5SS, UK aut NATIONALLICENCE 700 1- Todd John A. Wellcome Trust Centre for Human Genetics, Nuffield Department of Surgery, University of Oxford, Windmill Road, Headington, Oxford OX3 7BN, UK aut NATIONALLICENCE 773 0- Human Molecular Genetics Oxford University Press 5/7(1996-07), 1071-1074 0964-6906 5:7<1071 1996 5 hmg Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford