caa a22 4500 397574940 CHVBK 20180308164852.0 cr unu---uuuuu 161202e199607 xx s 000 0 eng 10.1093/hmg/5.7.869 doi (NATIONALLICENCE)oxford-10.1093/hmg/5.7.869 An RBM Homologue Maps to the Mouse Y Chromosome and is Expressed in Germ Cells [Elektronische Daten] [David J. Elliott, Kun Ma, Shona M. Kerr, Rekben Thakrar, Robert Speed, Ann C. Chandley, Howard Cooke] We have isolated a murine homologue of the human Y-linked RBM genes (previously termed YRRM), a gene family implicated in spermatogenesis and which encodes proteins containing an RNA recognition motif. A number of very similar copies of this gene (called Rbm) are present in the mouse. These mouse homologues are also Y-encoded, mapping on the short arm of the chromosome, proximal to Sry. Expression is confined to the testis, specifically the germ line on the basis of lack of expression in the germ-line negative testes of adult sex-reversed mice. The timing of Rbm transcription is regulated, with fetal message levels reaching a peak at 15 d.p.c. Transcripts are clearly detectable by 4 days after birth and reach their highest level at 14 d.p.p. which is the time at which the Y chromosome condenses during meiotic prophase. These results suggest that Rbm is functionally involved in germline RNA metabolism. © 1996 Oxford University Press Elliott David J. MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK aut Ma Kun MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK aut Kerr Shona M. MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK aut Thakrar Rekben MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK aut Speed Robert MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK aut Chandley Ann C. MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK aut Cooke Howard MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK aut Human Molecular Genetics Oxford University Press 5/7(1996-07), 869-874 0964-6906 5:7<869 1996 5 hmg https://doi.org/10.1093/hmg/5.7.869 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/hmg/5.7.869 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Elliott David J. MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK aut NATIONALLICENCE 700 1- Ma Kun MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK aut NATIONALLICENCE 700 1- Kerr Shona M. MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK aut NATIONALLICENCE 700 1- Thakrar Rekben MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK aut NATIONALLICENCE 700 1- Speed Robert MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK aut NATIONALLICENCE 700 1- Chandley Ann C. MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK aut NATIONALLICENCE 700 1- Cooke Howard MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK aut NATIONALLICENCE 773 0- Human Molecular Genetics Oxford University Press 5/7(1996-07), 869-874 0964-6906 5:7<869 1996 5 hmg Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford