caa a22 4500 397575122 CHVBK 20180308164853.0 cr unu---uuuuu 161202e199605 xx s 000 0 eng 10.1093/hmg/5.5.675 doi (NATIONALLICENCE)oxford-10.1093/hmg/5.5.675 A Member of the MAP Kinase Phosphatase Gene Family in Mouse Containing a Complex Trinucleotide Repeat in the Coding Region [Elektronische Daten] [A. M. Theodosiou, N. R. Rodrigues, M. A. Nesbit, H. J. Ambrose, H. Paterson, E. McLellan-Arnold, Y. Boyd, M. A. Leversha, N. Owen, D. J. Blake, A. Ashworth, K. E. Davies] We have identified a novel mouse gene encoding a protein that shows high homology to the dual-specificity tyrosine/threonine phosphatase family of proteins. The gene encodes a 5 kb transcript which is expressed predominantly in brain and lung and contains a translated complex trinucleotide repeat within the coding region. Using interspecific mouse backcross analysis, the gene has been localised to distal mouse chromosome 7. In human, homologous sequences are located in the syntenic region on distal chromosome 11p as well as to chromosome 10q11.2 and 10q22. The presence of a CG-rich trinucleotide repeat in the coding region provides a target for mutation which might result in loss of function or altered properties of this phos-phatase. © 1996 Oxford University Press Theodosiou A. M. Genetics Laboratory Biochemistry Department, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK aut Rodrigues N. R. Genetics Laboratory Biochemistry Department, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK aut Nesbit M. A. Genetics Laboratory Biochemistry Department, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK aut Ambrose H. J. Genetics Laboratory Biochemistry Department, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK aut Paterson H. CRC, Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK aut McLellan-Arnold E. CRC, Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK aut Boyd Y. MRC, Mammalian Genetics Unit, Harwell, Didcot, OX11 0RD, UK aut Leversha M. A. The Sanger Centre, Hinxton Hall, Cambridge, CB10 1RQ, UK aut Owen N. Genetics Laboratory Biochemistry Department, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK aut Blake D. J. Genetics Laboratory Biochemistry Department, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK aut Ashworth A. CRC, Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK aut Davies K. E. Genetics Laboratory Biochemistry Department, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK aut Human Molecular Genetics Oxford University Press 5/5(1996-05), 675-684 0964-6906 5:5<675 1996 5 hmg https://doi.org/10.1093/hmg/5.5.675 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/hmg/5.5.675 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Theodosiou A. M. Genetics Laboratory Biochemistry Department, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK aut NATIONALLICENCE 700 1- Rodrigues N. R. Genetics Laboratory Biochemistry Department, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK aut NATIONALLICENCE 700 1- Nesbit M. A. Genetics Laboratory Biochemistry Department, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK aut NATIONALLICENCE 700 1- Ambrose H. J. Genetics Laboratory Biochemistry Department, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK aut NATIONALLICENCE 700 1- Paterson H. CRC, Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK aut NATIONALLICENCE 700 1- McLellan-Arnold E. CRC, Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK aut NATIONALLICENCE 700 1- Boyd Y. MRC, Mammalian Genetics Unit, Harwell, Didcot, OX11 0RD, UK aut NATIONALLICENCE 700 1- Leversha M. A. The Sanger Centre, Hinxton Hall, Cambridge, CB10 1RQ, UK aut NATIONALLICENCE 700 1- Owen N. Genetics Laboratory Biochemistry Department, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK aut NATIONALLICENCE 700 1- Blake D. J. Genetics Laboratory Biochemistry Department, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK aut NATIONALLICENCE 700 1- Ashworth A. CRC, Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK aut NATIONALLICENCE 700 1- Davies K. E. Genetics Laboratory Biochemistry Department, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK aut NATIONALLICENCE 773 0- Human Molecular Genetics Oxford University Press 5/5(1996-05), 675-684 0964-6906 5:5<675 1996 5 hmg Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford