caa a22 4500 397575173 CHVBK 20180308164853.0 cr unu---uuuuu 161202e199609 xx s 000 0 eng 10.1093/hmg/5.Supplement_1.1495 doi (NATIONALLICENCE)oxford-10.1093/hmg/5.Supplement_1.1495 Recombination and nondisjunction in humans and flies [Elektronische Daten] [Kara E. Koehler, R. Scott Hawley, Stephanie Sherman, Terry Hassold] Recent studies of Drosophila and humans indicate that aberrant genetic recombination is an important component of nondisjunction in both species. In both, a proportion of nondisjunction is associated with failure to pair and/or recombine and in both, exchanges which are either too distal or too proximal increase the likelihood of malsegregation. In this review we provide two perspectives on these observations: first, a review of exchange and chromosome segregation in model organisms, focusing on Drosophila, and secondly an overview of nondisjunction in humans. This format allows us to describe the paradigms developed from studies of model organisms and to ask whether these paradigms apply to the human situation. © 1996 Oxford University Press Koehler Kara E. Department of Genetics, Section of Molecular and Cellular Biology, University of California at Davis, Davis, CA 95616, USA aut Hawley R. Scott Department of Genetics, Section of Molecular and Cellular Biology, University of California at Davis, Davis, CA 95616, USA aut Sherman Stephanie Department of Genetics and Molecular Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA aut Hassold Terry Department of Genetics and The Center for Human Genetics, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH 44106, USA aut Human Molecular Genetics Oxford University Press 5/Supplement_1(1996-09), 1495-1504 0964-6906 5:Supplement_1<1495 1996 5 hmg https://doi.org/10.1093/hmg/5.Supplement_1.1495 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/hmg/5.Supplement_1.1495 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Koehler Kara E. Department of Genetics, Section of Molecular and Cellular Biology, University of California at Davis, Davis, CA 95616, USA aut NATIONALLICENCE 700 1- Hawley R. Scott Department of Genetics, Section of Molecular and Cellular Biology, University of California at Davis, Davis, CA 95616, USA aut NATIONALLICENCE 700 1- Sherman Stephanie Department of Genetics and Molecular Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA aut NATIONALLICENCE 700 1- Hassold Terry Department of Genetics and The Center for Human Genetics, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH 44106, USA aut NATIONALLICENCE 773 0- Human Molecular Genetics Oxford University Press 5/Supplement_1(1996-09), 1495-1504 0964-6906 5:Supplement_1<1495 1996 5 hmg Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford