caa a22 4500 397575270 CHVBK 20180308164854.0 cr unu---uuuuu 161202e199608 xx s 000 0 eng 10.1093/hmg/5.8.1123 doi (NATIONALLICENCE)oxford-10.1093/hmg/5.8.1123 Biallelic Expression of the IGF2 Gene in Human Breast Disease [Elektronische Daten] [Amanda H. McCann, Nicola Miller, Anne O'Meara, Inge Pedersen, Karina Keogh, Thomas Gorey, Peter A. Dervan] We examined the imprinting status of the insulin-like growth factor II gene (IGF2) in a series of 20 human breast disease samples to determine if disrupted imprinting (as evidenced by biallelic expression), was a demonstrable mechanism of altered gene expression. These samples included benign (n = 7) and malignant breast lesions (n = 13). Biallelic expression of IGF2 was detectable in 67% of benign and 60% of malignant informative breast lesions. Three informative reduction mastectomies displayed normal IGF2 imprinting. The presence of this alteration in human breast tissue is a novel finding, and may contribute to tumorigenesis, possibly by favouring an enhanced proliferative milieu, during which additional mutations could occur. © 1996 Oxford University Press McCann Amanda H. Department of Pathology and the Biotechnology Centre, Laboratory I, G08, University College Dublin (UCD), Belfield, Dublin 4, Ireland aut Miller Nicola Department of Pathology and the Biotechnology Centre, Laboratory I, G08, University College Dublin (UCD), Belfield, Dublin 4, Ireland aut O'Meara Anne Our Lady's Hospital for Sick Children, Crumlin, Dublin 12, Ireland aut Pedersen Inge Department of Pathology and the Biotechnology Centre, Laboratory I, G08, University College Dublin (UCD), Belfield, Dublin 4, Ireland aut Keogh Karina Department of Pathology and the Biotechnology Centre, Laboratory I, G08, University College Dublin (UCD), Belfield, Dublin 4, Ireland aut Gorey Thomas Department of Surgery, UCD, Belfield, Dublin 4, Ireland aut Dervan Peter A. Department of Pathology and the Biotechnology Centre, Laboratory I, G08, University College Dublin (UCD), Belfield, Dublin 4, Ireland aut Human Molecular Genetics Oxford University Press 5/8(1996-08), 1123-1127 0964-6906 5:8<1123 1996 5 hmg https://doi.org/10.1093/hmg/5.8.1123 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/hmg/5.8.1123 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- McCann Amanda H. Department of Pathology and the Biotechnology Centre, Laboratory I, G08, University College Dublin (UCD), Belfield, Dublin 4, Ireland aut NATIONALLICENCE 700 1- Miller Nicola Department of Pathology and the Biotechnology Centre, Laboratory I, G08, University College Dublin (UCD), Belfield, Dublin 4, Ireland aut NATIONALLICENCE 700 1- O'Meara Anne Our Lady's Hospital for Sick Children, Crumlin, Dublin 12, Ireland aut NATIONALLICENCE 700 1- Pedersen Inge Department of Pathology and the Biotechnology Centre, Laboratory I, G08, University College Dublin (UCD), Belfield, Dublin 4, Ireland aut NATIONALLICENCE 700 1- Keogh Karina Department of Pathology and the Biotechnology Centre, Laboratory I, G08, University College Dublin (UCD), Belfield, Dublin 4, Ireland aut NATIONALLICENCE 700 1- Gorey Thomas Department of Surgery, UCD, Belfield, Dublin 4, Ireland aut NATIONALLICENCE 700 1- Dervan Peter A. Department of Pathology and the Biotechnology Centre, Laboratory I, G08, University College Dublin (UCD), Belfield, Dublin 4, Ireland aut NATIONALLICENCE 773 0- Human Molecular Genetics Oxford University Press 5/8(1996-08), 1123-1127 0964-6906 5:8<1123 1996 5 hmg Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford