caa a22 4500 397575564 CHVBK 20180308164855.0 cr unu---uuuuu 161202e199609 xx s 000 0 eng 10.1093/hmg/5.Supplement_1.1471 doi (NATIONALLICENCE)oxford-10.1093/hmg/5.Supplement_1.1471 Transcription factor genes and the developing eye: a genetic perspective [Elektronische Daten] [Carol Freund, D. Jonathan Horsford, Roderick R. McInnes] We review the current knowledge of transcription factors in mammalian eye development. The 14 transcription factors presently known to be required for eye formation are examined in some detail, incorporating data from both humans and rodents. Aspects of the biochemistry, expression patterns, genetics, mutant phenotypes, and biological insights acquired from the examination of loss-of-function mutations are summarized. The other 32 tissue-restricted transcription factors that are currently known to be expressed in the developing or mature mammalian eye are tabulated, together with the timing and site of their ocular expression; the requirement for most of these genes in the eye is unknown. Contributions to mammalian eye development from the study of the genetics of the Drosophila eye are discussed briefly. Identification of the entire cohort of transcription factors required for eye development is an essential first step towards understanding the mechanisms underlying eye morphogenesis and differentiation, and the molecular basis of inherited eye abnormalities in humans. © 1996 Oxford University Press Freund Carol Department of Genetics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada aut Horsford D. Jonathan Department of Genetics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada aut McInnes Roderick R. Department of Genetics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada aut Human Molecular Genetics Oxford University Press 5/Supplement_1(1996-09), 1471-1488 0964-6906 5:Supplement_1<1471 1996 5 hmg https://doi.org/10.1093/hmg/5.Supplement_1.1471 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/hmg/5.Supplement_1.1471 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Freund Carol Department of Genetics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Horsford D. Jonathan Department of Genetics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- McInnes Roderick R. Department of Genetics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada aut NATIONALLICENCE 773 0- Human Molecular Genetics Oxford University Press 5/Supplement_1(1996-09), 1471-1488 0964-6906 5:Supplement_1<1471 1996 5 hmg Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford