caa a22 4500 397575726 CHVBK 20180308164855.0 cr unu---uuuuu 161202e199609 xx s 000 0 eng 10.1093/hmg/5.Supplement_1.1405 doi (NATIONALLICENCE)oxford-10.1093/hmg/5.Supplement_1.1405 Genetic analysis of atherosclerosis: a research paradigm for the common chronic diseases [Elektronische Daten] [Eric Boerwinkle, Darrel L. Ellsworth, D. Michael Hallman, Alan Biddinger] Rapid discoveries of novel and unexpected disease-associated genes for atherosclerotic coronary artery disease (CAD) are anticipated as genomic maps become more detailed and methods for mapping complex disease phenotypes become more refined. Although establishing association or linkage of a marker locus to a CAD susceptibility gene is an important first step, the long-term goal should be to define the underlying functional mutations and explore possible disease mechanisms, including the gene—environment interactions that culminate in clinically apparent disease. This review will define a contemporary research paradigm for study of the genetics of CAD and other common chronic diseases using the tools of modern molecular biology and human genetics. © 1996 Oxford University Press Boerwinkle Eric Human Genetics Center, University of Texas - Houston Health Science Center, PO Box 20334, Houston, TX 77225, USA aut Ellsworth Darrel L. Human Genetics Center, University of Texas - Houston Health Science Center, PO Box 20334, Houston, TX 77225, USA aut Hallman D. Michael Human Genetics Center, University of Texas - Houston Health Science Center, PO Box 20334, Houston, TX 77225, USA aut Biddinger Alan Human Genetics Center, University of Texas - Houston Health Science Center, PO Box 20334, Houston, TX 77225, USA aut Human Molecular Genetics Oxford University Press 5/Supplement_1(1996-09), 1405-1410 0964-6906 5:Supplement_1<1405 1996 5 hmg https://doi.org/10.1093/hmg/5.Supplement_1.1405 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/hmg/5.Supplement_1.1405 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Boerwinkle Eric Human Genetics Center, University of Texas - Houston Health Science Center, PO Box 20334, Houston, TX 77225, USA aut NATIONALLICENCE 700 1- Ellsworth Darrel L. Human Genetics Center, University of Texas - Houston Health Science Center, PO Box 20334, Houston, TX 77225, USA aut NATIONALLICENCE 700 1- Hallman D. Michael Human Genetics Center, University of Texas - Houston Health Science Center, PO Box 20334, Houston, TX 77225, USA aut NATIONALLICENCE 700 1- Biddinger Alan Human Genetics Center, University of Texas - Houston Health Science Center, PO Box 20334, Houston, TX 77225, USA aut NATIONALLICENCE 773 0- Human Molecular Genetics Oxford University Press 5/Supplement_1(1996-09), 1405-1410 0964-6906 5:Supplement_1<1405 1996 5 hmg Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford