caa a22 4500 397575866 CHVBK 20180308164856.0 cr unu---uuuuu 161202e199603 xx s 000 0 eng 10.1093/hmg/5.3.339 doi (NATIONALLICENCE)oxford-10.1093/hmg/5.3.339 A Radiation Hybrid Map of the Human Genome [Elektronische Daten] [Gabor Gyapay, Karin Schmitt, Cécile Fizames, Hywel Jones, Nathalie Vega-Czarny, Dominique Spillett, Delphine Muselet, Jean-François Prud'Homme, Colette Dib, Charles Auffray, Jean Morissette, Jean Weissenbach, Peter N. Goodfellow] We have developed a panel of whole-genome radiation hybrids by fusing irradiated diploid human fibroblasts with recipient hamster cells. This panel of 168 cell lines has been typed with microsatellite markers of known genetic location. Of 711 AFM genetic markers 404 were selected to construct a robust framework map that spans all the autosomes and the X chromosome. To demonstrate the utility of the panel, 374 expressed sequence tags (ESTs) previously assigned to chromosomes 1, 2, 14 and 16 were localized on this map. All of these ESTs could be positioned by pairwise linkage to one of the framework markers with a LOD score of greater than 8. The whole genome radiation hybrid panel described here has been used as the starting material for the Genebridge4 panel that is being made widely available for genome mapping projects. © 1996 Oxford University Press Gyapay Gabor CNRS URA 1922, Généthon, 1 rue de l'Internationale, 91000 Evry, France aut Schmitt Karin University of Cambridge, Department of Genetics, Downing Street, Cambridge, UK aut Fizames Cécile CNRS URA 1922, Généthon, 1 rue de l'Internationale, 91000 Evry, France aut Jones Hywel University of Cambridge, Department of Genetics, Downing Street, Cambridge, UK aut Vega-Czarny Nathalie CNRS URA 1922, Généthon, 1 rue de l'Internationale, 91000 Evry, France aut Spillett Dominique University of Cambridge, Department of Genetics, Downing Street, Cambridge, UK aut Muselet Delphine CNRS URA 1922, Généthon, 1 rue de l'Internationale, 91000 Evry, France aut Prud'Homme Jean-François CNRS URA 1922, Généthon, 1 rue de l'Internationale, 91000 Evry, France aut Dib Colette CNRS URA 1922, Généthon, 1 rue de l'Internationale, 91000 Evry, France aut Auffray Charles Genexpress, Généthon and CNRS UPR 420, 7 rue Guy Mocquet, 94801 Villejuif, France aut Morissette Jean CNRS URA 1922, Généthon, 1 rue de l'Internationale, 91000 Evry, France aut Weissenbach Jean CNRS URA 1922, Généthon, 1 rue de l'Internationale, 91000 Evry, France aut Goodfellow Peter N. University of Cambridge, Department of Genetics, Downing Street, Cambridge, UK aut Human Molecular Genetics Oxford University Press 5/3(1996-03), 339-346 0964-6906 5:3<339 1996 5 hmg https://doi.org/10.1093/hmg/5.3.339 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/hmg/5.3.339 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gyapay Gabor CNRS URA 1922, Généthon, 1 rue de l'Internationale, 91000 Evry, France aut NATIONALLICENCE 700 1- Schmitt Karin University of Cambridge, Department of Genetics, Downing Street, Cambridge, UK aut NATIONALLICENCE 700 1- Fizames Cécile CNRS URA 1922, Généthon, 1 rue de l'Internationale, 91000 Evry, France aut NATIONALLICENCE 700 1- Jones Hywel University of Cambridge, Department of Genetics, Downing Street, Cambridge, UK aut NATIONALLICENCE 700 1- Vega-Czarny Nathalie CNRS URA 1922, Généthon, 1 rue de l'Internationale, 91000 Evry, France aut NATIONALLICENCE 700 1- Spillett Dominique University of Cambridge, Department of Genetics, Downing Street, Cambridge, UK aut NATIONALLICENCE 700 1- Muselet Delphine CNRS URA 1922, Généthon, 1 rue de l'Internationale, 91000 Evry, France aut NATIONALLICENCE 700 1- Prud'Homme Jean-François CNRS URA 1922, Généthon, 1 rue de l'Internationale, 91000 Evry, France aut NATIONALLICENCE 700 1- Dib Colette CNRS URA 1922, Généthon, 1 rue de l'Internationale, 91000 Evry, France aut NATIONALLICENCE 700 1- Auffray Charles Genexpress, Généthon and CNRS UPR 420, 7 rue Guy Mocquet, 94801 Villejuif, France aut NATIONALLICENCE 700 1- Morissette Jean CNRS URA 1922, Généthon, 1 rue de l'Internationale, 91000 Evry, France aut NATIONALLICENCE 700 1- Weissenbach Jean CNRS URA 1922, Généthon, 1 rue de l'Internationale, 91000 Evry, France aut NATIONALLICENCE 700 1- Goodfellow Peter N. University of Cambridge, Department of Genetics, Downing Street, Cambridge, UK aut NATIONALLICENCE 773 0- Human Molecular Genetics Oxford University Press 5/3(1996-03), 339-346 0964-6906 5:3<339 1996 5 hmg Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford