caa a22 4500 397575882 CHVBK 20180308164856.0 cr unu---uuuuu 161202e199606 xx s 000 0 eng 10.1093/hmg/5.6.783 doi (NATIONALLICENCE)oxford-10.1093/hmg/5.6.783 Genomic Imprinting of Human p57KIP2 and Its Reduced Expression in Wilms' Tumors [Elektronische Daten] [Izuho Hatada, Johji Inazawa, Tatsuo Abe, Masahiro Nakayama, Yasuhiko Kaneko, Yoshihiro Jinno, Norio Niikawa, Hirofumi Ohashi, Yoshimitsu Fukushima, Kazuki Iida, Chikao Yutani, Shun-ichi Takahashi, Yoshihide Chiba, Sachiko Ohishi, Tsunehiro Mukai, Izuho Hatada, Johji Inazawa, Tatsuo Abe, Masahiro Nakayama, Yasuhiko Kaneko, Yoshihiro Jinno, Norio Niikawa, Hirofumi Ohashi, Yoshimitsu Fukushima, Kazuki Iida, Chikao Yutani, Shun-ichi Takahashi, Yoshihide Chiba, Sachiko Ohishi, Tsunehiro Mukai] p57KIP2 is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. The gene encoding human p57KIP2is located on chromosome 11p15.5, a region implicated in both sporadic cancers and Beckwith-Wiedemann syndrome (BWS), a cancer syndrome, making it a tumor suppressor candidate. Several types of childhood tumors including Wilms' tumor, adrenocortical carcinoma and rhabdomyosarcoma display a specific loss of maternal 11p15 alleles, suggesting that genomic imprinting plays an important part. Genetic analysis of the familial BWS has indicated maternal carriers and suggested a role in genomic imprinting. Previously, we demonstrated that p57KIP2is imprinted in the mouse. Here we describe the genomic imprinting of human p57KIP2and the reduction of its expression in Wilms' tumors. High resolution mapping locates p57KIP2 in the region responsible for both tumor suppressivity and BWS. © 1996 Oxford University Press Hatada Izuho National Cardiovascular Center Research Institute, 5-7-1, Fujishiro-dai, Suita, Osaka 565, Japan aut Inazawa Johji Kyoto Prefectural University of Medicine, Kajii-cho, Hirokoji-Kawaramachi, Kamigyo-ku, Kyoto 602, Japan aut Abe Tatsuo Kyoto Prefectural University of Medicine, Kajii-cho, Hirokoji-Kawaramachi, Kamigyo-ku, Kyoto 602, Japan aut Nakayama Masahiro Osaka Medical Center and Research Institute for Maternal and Child Health, 840 Murodou-cyo, Izumi, Osaka 565, Japan aut Kaneko Yasuhiko Saitama Cancer Center, 818 Komuro, Ina, Saitama 362, Japan aut Jinno Yoshihiro Nagasaki University School of Medicine, 1-12-4 Sakamoto, Nagasaki 852, Japan aut Niikawa Norio Nagasaki University School of Medicine, 1-12-4 Sakamoto, Nagasaki 852, Japan aut Ohashi Hirofumi Saitama Children's Medical Center, 2100 Magome, Iwatsuki, Saitama 339, Japan aut Fukushima Yoshimitsu Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390, Japan aut Iida Kazuki National Cardiovascular Hospital, 5-7-1, Fujishiro-dai, Suita, Osaka 565, Japan aut Yutani Chikao National Cardiovascular Hospital, 5-7-1, Fujishiro-dai, Suita, Osaka 565, Japan aut Takahashi Shun-ichi National Cardiovascular Hospital, 5-7-1, Fujishiro-dai, Suita, Osaka 565, Japan aut Chiba Yoshihide National Cardiovascular Hospital, 5-7-1, Fujishiro-dai, Suita, Osaka 565, Japan aut Ohishi Sachiko National Cardiovascular Center Research Institute, 5-7-1, Fujishiro-dai, Suita, Osaka 565, Japan aut Mukai Tsunehiro National Cardiovascular Center Research Institute, 5-7-1, Fujishiro-dai, Suita, Osaka 565, Japan aut Human Molecular Genetics Oxford University Press 5/6(1996-06), 783-788 0964-6906 5:6<783 1996 5 hmg https://doi.org/10.1093/hmg/5.6.783 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/hmg/5.6.783 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hatada Izuho National Cardiovascular Center Research Institute, 5-7-1, Fujishiro-dai, Suita, Osaka 565, Japan aut NATIONALLICENCE 700 1- Inazawa Johji Kyoto Prefectural University of Medicine, Kajii-cho, Hirokoji-Kawaramachi, Kamigyo-ku, Kyoto 602, Japan aut NATIONALLICENCE 700 1- Abe Tatsuo Kyoto Prefectural University of Medicine, Kajii-cho, Hirokoji-Kawaramachi, Kamigyo-ku, Kyoto 602, Japan aut NATIONALLICENCE 700 1- Nakayama Masahiro Osaka Medical Center and Research Institute for Maternal and Child Health, 840 Murodou-cyo, Izumi, Osaka 565, Japan aut NATIONALLICENCE 700 1- Kaneko Yasuhiko Saitama Cancer Center, 818 Komuro, Ina, Saitama 362, Japan aut NATIONALLICENCE 700 1- Jinno Yoshihiro Nagasaki University School of Medicine, 1-12-4 Sakamoto, Nagasaki 852, Japan aut NATIONALLICENCE 700 1- Niikawa Norio Nagasaki University School of Medicine, 1-12-4 Sakamoto, Nagasaki 852, Japan aut NATIONALLICENCE 700 1- Ohashi Hirofumi Saitama Children's Medical Center, 2100 Magome, Iwatsuki, Saitama 339, Japan aut NATIONALLICENCE 700 1- Fukushima Yoshimitsu Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390, Japan aut NATIONALLICENCE 700 1- Iida Kazuki National Cardiovascular Hospital, 5-7-1, Fujishiro-dai, Suita, Osaka 565, Japan aut NATIONALLICENCE 700 1- Yutani Chikao National Cardiovascular Hospital, 5-7-1, Fujishiro-dai, Suita, Osaka 565, Japan aut NATIONALLICENCE 700 1- Takahashi Shun-ichi National Cardiovascular Hospital, 5-7-1, Fujishiro-dai, Suita, Osaka 565, Japan aut NATIONALLICENCE 700 1- Chiba Yoshihide National Cardiovascular Hospital, 5-7-1, Fujishiro-dai, Suita, Osaka 565, Japan aut NATIONALLICENCE 700 1- Ohishi Sachiko National Cardiovascular Center Research Institute, 5-7-1, Fujishiro-dai, Suita, Osaka 565, Japan aut NATIONALLICENCE 700 1- Mukai Tsunehiro National Cardiovascular Center Research Institute, 5-7-1, Fujishiro-dai, Suita, Osaka 565, Japan aut NATIONALLICENCE 773 0- Human Molecular Genetics Oxford University Press 5/6(1996-06), 783-788 0964-6906 5:6<783 1996 5 hmg Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford