caa a22 4500 397576994 CHVBK 20180308164858.0 cr unu---uuuuu 161202e199603 xx s 000 0 eng 10.1093/oxfordjournals.pubmed.a024466 doi (NATIONALLICENCE)oxford-10.1093/oxfordjournals.pubmed.a024466 The epidemiology of Down syndrome in four counties in Ireland 1981-1990 [Elektronische Daten] [Z. Johnson, D. Lillis, V. Delany, C. Hayes, P. Dack] Background We conducted a descriptive epidemiological study of Down syndrome (DS) in the four Irish counties (Dublin, Kildare, Wicklow and Galway) covered by EUROCAT registries of congenital malformations for the years 1981-1990. Methods EUROCAT registries, which cover defined populations, use multiple sources for case ascertainment. All DS cases born between 1 January 1981 and 31 December 1990 to mothers resident in the four counties were identified. Crude birth prevalence rates and maternal agestandardized rates (SPRs) were calculated for each county and for each year in the study period. The prevalence of DS by maternal age grouped in five-year periods and the risk for each five-year group were also estimated. Results The crude birth prevalence for the four counties was 18⋅5/10 000 for all births and 18⋅3 for live births. There was a fall in the total number of DS births over the decade, but less change in the crude birth prevalence owing to an increase in the proportion of mothers aged 35 + . Galway had the highest crude birth prevalence of DS (23⋅5/10 000) but the SPR was within average for the four counties as a whole - 110⋅3, 95 per cent confidence interval (Cl) 86⋅7-139. The risk of having a DS child increased 70-fold from 1:1841 at age 15-19 to 1:26 at 45 years or older. Nearly half of all DS cases (47⋅4 per cent) had at least one additional anomaly. Conclusions The parts of Ireland covered by EUROCAT have a high birth prevalence of DS births as compared with some other countries, but the maternal age-specific rates are not substantially different from those in large international studies. © Oxford University Press Articles nationallicence Down syndrome nationallicence epidemiology nationallicence maternal age nationallicence abnormalities nationallicence Johnson Z. Dublin EUROCAT Registry, Health Information Unit, Eastern Health Board, Dr Steevens Hospital Dublin 8, Ireland aut Lillis D. Galway EUROCAT Registry, Department of Paediatrics, University College Hospital Galway, Ireland aut Delany V. Dublin EUROCAT Registry aut Hayes C. Dublin EUROCAT Registry aut Dack P. Dublin EUROCAT Registry aut Journal of Public Health Oxford University Press 18/1(1996-03), 78-86 1741-3842 18:1<78 1996 18 pubmed https://doi.org/10.1093/oxfordjournals.pubmed.a024466 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/oxfordjournals.pubmed.a024466 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Johnson Z. Dublin EUROCAT Registry, Health Information Unit, Eastern Health Board, Dr Steevens Hospital Dublin 8, Ireland aut NATIONALLICENCE 700 1- Lillis D. Galway EUROCAT Registry, Department of Paediatrics, University College Hospital Galway, Ireland aut NATIONALLICENCE 700 1- Delany V. Dublin EUROCAT Registry aut NATIONALLICENCE 700 1- Hayes C. Dublin EUROCAT Registry aut NATIONALLICENCE 700 1- Dack P. Dublin EUROCAT Registry aut NATIONALLICENCE 773 0- Journal of Public Health Oxford University Press 18/1(1996-03), 78-86 1741-3842 18:1<78 1996 18 pubmed Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford