caa a22 4500 397577087 CHVBK 20180308164859.0 cr unu---uuuuu 161202e199603 xx s 000 0 eng 10.1093/oxfordjournals.pubmed.a024458 doi (NATIONALLICENCE)oxford-10.1093/oxfordjournals.pubmed.a024458 Screening and the new genetics; a public health perspective on the ethical debate [Elektronische Daten] [David H. Stone, Susie Stewart] Advances in the diagnostic applications of molecular genetics have made possible the identification of recessive carrier states in the population. The debate surrounding screening for cystic fibrosis therefore has a public health significance which transcends that specific disorder. The two most frequently cited objectives of screening for a recessive carrier state are to reduce the prevalence of the disorder and to inform the reproductive choices of individuals and couples at risk. The latter aim represents a paradigm shift in the philosophy of screening in that no preventive principle is involved. Instead, information is regarded as worth while in itself, regardless of outcome. The authors argue that the benefits arising from the information generated in the course of genetic carrier screening cannot be presumed merely by asserting a ‘right to know' ethical imperative, and draw attention to the danger that a combination of technical capability, professional zeal and consumer demand will override currently accepted screening principles. In this event, future efforts to subject screening programmes to rational evaluation could be undermined. © Oxford University Press For Debate nationallicence Stone David H. Department of Child Health, University of Glasgow, Yorkhill Hospital, Glasgow G3 8SJ aut Stewart Susie Department of Child Health, University of Glasgow, Yorkhill Hospital, Glasgow G3 8SJ aut Journal of Public Health Oxford University Press 18/1(1996-03), 3-5 1741-3842 18:1<3 1996 18 pubmed https://doi.org/10.1093/oxfordjournals.pubmed.a024458 text/html Onlinezugriff via DOI 1 other jats NATIONALLICENCE 856 40 https://doi.org/10.1093/oxfordjournals.pubmed.a024458 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Stone David H. Department of Child Health, University of Glasgow, Yorkhill Hospital, Glasgow G3 8SJ aut NATIONALLICENCE 700 1- Stewart Susie Department of Child Health, University of Glasgow, Yorkhill Hospital, Glasgow G3 8SJ aut NATIONALLICENCE 773 0- Journal of Public Health Oxford University Press 18/1(1996-03), 3-5 1741-3842 18:1<3 1996 18 pubmed Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford