caa a22 4500 397581440 CHVBK 20180308164908.0 cr unu---uuuuu 161202e199611 xx s 000 0 eng 10.1093/cercor/6.6.823 doi (NATIONALLICENCE)oxford-10.1093/cercor/6.6.823 The Parahippocampus Subserves Topographical Learning in Man [Elektronische Daten] [Geoffrey K. Aguirre, John A. Detre, David C. Alsop, Mark D'Esposito] The hippocampus has been proposed as the site of neural representation of large-scale environmental space, based upon the identification of place cells (neurons with receptive fields for current position in the environment) within the rat hippocampus and the demonstration that hippocampal lesions impair place learning in therat. The inability to identify place cells within the monkey hippocampus and the observation that unilateral hippocampal lesions do not selectively impair topographic behavior in humans suggest that alternate regions may subserve this function in man. To examine the contribution of the hippocampus and adjacent medial-temporal lobe structures to topographic learning in the human, a ‘virtual' maze was used as a task environment during functional magnetic resonance imaging studies. During the learning and recall of topographic information, medial-temporal activity was confined to the para- hippocampal gyri. This activity accords well with the lesion site known to produce topographical disorientation in humans. Activity was also observed in cortical areas known to project to the parahippocampus and previously proposed to contribute to a network subserving spatially guided behavior. © 1996 Oxford University Press Articles nationallicence Aguirre Geoffrey K. Departments of Neurology, University of Pennsylvania Philadelphia, PA 19104, USA aut Detre John A. Departments of Neurology, University of Pennsylvania Philadelphia, PA 19104, USA aut Alsop David C. Departments of Radiology, University of Pennsylvania Philadelphia, PA 19104, USA aut D'Esposito Mark Departments of Neurology, University of Pennsylvania Philadelphia, PA 19104, USA aut Cerebral Cortex Oxford University Press 6/6(1996-11), 823-829 1047-3211 6:6<823 1996 6 cercor https://doi.org/10.1093/cercor/6.6.823 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/cercor/6.6.823 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Aguirre Geoffrey K. Departments of Neurology, University of Pennsylvania Philadelphia, PA 19104, USA aut NATIONALLICENCE 700 1- Detre John A. Departments of Neurology, University of Pennsylvania Philadelphia, PA 19104, USA aut NATIONALLICENCE 700 1- Alsop David C. Departments of Radiology, University of Pennsylvania Philadelphia, PA 19104, USA aut NATIONALLICENCE 700 1- D'Esposito Mark Departments of Neurology, University of Pennsylvania Philadelphia, PA 19104, USA aut NATIONALLICENCE 773 0- Cerebral Cortex Oxford University Press 6/6(1996-11), 823-829 1047-3211 6:6<823 1996 6 cercor Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford