caa a22 4500 397581483 CHVBK 20180308164908.0 cr unu---uuuuu 161202e199611 xx s 000 0 eng 10.1093/cercor/6.6.830 doi (NATIONALLICENCE)oxford-10.1093/cercor/6.6.830 Three-Dimensional Fractal Analysis of the White Matter Surface from Magnetic Resonance Images of the Human Brain [Elektronische Daten] [S. L. Free, S. M. Sisodiya, M. J. Cook, D. R. Fish, S. D. Shorvon] The convolutions of the cerebral cortex are difficult to describe and delineate. Our understanding of the development of the brain and its associated maldevelopment would be assisted by quantitative analysis of the cortex. Volumetric magnetic resonance (MR) imaging provides high-resolution anatomical data from which we can reconstruct the white matter as a three-dimensional object and extract its surface (the grey/white matter interface). Three-dimensional fractal analysis of this surface is a method of quantifying the surface complexity dependent upon the variation of the surface area under different scales of inspection. We estimate the fractal dimension of the white matter surface for each hemisphere and 10 coronal blocks of each hemisphere in 30 normal adult subjects. These values are tightly distributed and have been used to define a normal range of fractal dimensions. Abnormal fractal dimensions were found in 8/16 subjects with epilepsy and a gyral abnormality observed on routine MR imaging; and in 9/23 subjects with epilepsy and normal routine MR imaging. These analytical techniques offer additional information about the structure of the cortex in normal brains and about abnormalities of structure in subjects with suspected but unobserved structural abnormalites. © 1996 Oxford University Press Articles nationallicence Free S. L. Epilepsy Research Group, Institute of Neurology Queen Square, London, UK aut Sisodiya S. M. Epilepsy Research Group, Institute of Neurology Queen Square, London, UK aut Cook M. J. St Vincent's Hospital Fitzroy, Australia aut Fish D. R. Epilepsy Research Group, Institute of Neurology Queen Square, London, UK aut Shorvon S. D. Epilepsy Research Group, Institute of Neurology Queen Square, London, UK aut Cerebral Cortex Oxford University Press 6/6(1996-11), 830-836 1047-3211 6:6<830 1996 6 cercor https://doi.org/10.1093/cercor/6.6.830 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/cercor/6.6.830 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Free S. L. Epilepsy Research Group, Institute of Neurology Queen Square, London, UK aut NATIONALLICENCE 700 1- Sisodiya S. M. Epilepsy Research Group, Institute of Neurology Queen Square, London, UK aut NATIONALLICENCE 700 1- Cook M. J. St Vincent's Hospital Fitzroy, Australia aut NATIONALLICENCE 700 1- Fish D. R. Epilepsy Research Group, Institute of Neurology Queen Square, London, UK aut NATIONALLICENCE 700 1- Shorvon S. D. Epilepsy Research Group, Institute of Neurology Queen Square, London, UK aut NATIONALLICENCE 773 0- Cerebral Cortex Oxford University Press 6/6(1996-11), 830-836 1047-3211 6:6<830 1996 6 cercor Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford