caa a22 4500 397581580 CHVBK 20180308164908.0 cr unu---uuuuu 161202e199603 xx s 000 0 eng 10.1093/cercor/6.2.297 doi (NATIONALLICENCE)oxford-10.1093/cercor/6.2.297 Relation between Patterns of Intrinsic Lateral Connectivity, Ocular Dominance, and Cytochrome Oxidase-Reactive Regions in Macaque Monkey Striate Cortex [Elektronische Daten] [Takashi Yoshioka, Gary G. Blasdel, Jonathan B. Levitt, Jennifer S. Lund] To help understand the role of long-range, clustered lateral connections in the superficial layers of macaque striate cortex (area V1), we have examined the relationship of the patterns of intrinsic connections to cytochrome oxidase (CO) blobs, interblobs, and ocular dominance (OD) bands, using biocytin based neuroanatomical tracing, CO histochemistry, and optical imaging. Microinjections of biocytin in layer 3 resulted in an asymmetric field (average anisotropy of 1.8; maximum spread—3.7 mm) of labeled axon terminal clusters in layers 1-3, with the longer axis of the label spread oriented orthogonal to the rows of blobs and imaged OD stripes, parallel to the V1/V2 border. These labeled terminal patches (n = 186) from either blob or interblob injections (n = 20) revealed a 71% (132 out of 186) commitment of patches to the same compartment as the injection site; 11% (20 out of 186) to the opposite compartment, and 18% (34 out of 186) to borders of blob-interblob compartments, indicating that the connectivity pattern is not strictly blob to blob, or interblob to interblob (p < 0.005; $$$2) In injections placed within single OD domains (n = 11), 54% of the resulting labeled terminal patches (43 out of 79) fell into the same OD territories as the injection sites, 28% (22 out of 79) into the opposite OD regions, and 18% (14 out of 79) on borders, showing some connectional bias toward same-eye compartments (p < 0.02; ANOVA). Individual injection cases, however, varied in the degree (50-100% for CO patterns, 22-100% for 0D patterns) to which they showed same-compartment connectivity. These results reveal that while connectivity between similar compartments predominates (e.g., blob to blob, right eye column to right eye column), interactions do occur between functionally different regions. © 1996 Oxford University Press Articles nationallicence Yoshioka Takashi Krieger Mind/Brain Institute, Johns Hopkins University Baltimore, Maryland 21218 aut Blasdel Gary G. Department of Neurobiology, Harvard Medical School Boston, Massachusetts 02115 aut Levitt Jonathan B. Department of Visual Science, Institute of Ophthalmology, University of London London EC1V 9EL, United Kingdom aut Lund Jennifer S. Department of Visual Science, Institute of Ophthalmology, University of London London EC1V 9EL, United Kingdom aut Cerebral Cortex Oxford University Press 6/2(1996-03), 297-310 1047-3211 6:2<297 1996 6 cercor https://doi.org/10.1093/cercor/6.2.297 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/cercor/6.2.297 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yoshioka Takashi Krieger Mind/Brain Institute, Johns Hopkins University Baltimore, Maryland 21218 aut NATIONALLICENCE 700 1- Blasdel Gary G. Department of Neurobiology, Harvard Medical School Boston, Massachusetts 02115 aut NATIONALLICENCE 700 1- Levitt Jonathan B. Department of Visual Science, Institute of Ophthalmology, University of London London EC1V 9EL, United Kingdom aut NATIONALLICENCE 700 1- Lund Jennifer S. Department of Visual Science, Institute of Ophthalmology, University of London London EC1V 9EL, United Kingdom aut NATIONALLICENCE 773 0- Cerebral Cortex Oxford University Press 6/2(1996-03), 297-310 1047-3211 6:2<297 1996 6 cercor Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford