caa a22 4500 397581599 CHVBK 20180308164908.0 cr unu---uuuuu 161202e199603 xx s 000 0 eng 10.1093/cercor/6.2.226 doi (NATIONALLICENCE)oxford-10.1093/cercor/6.2.226 Functional Anatomy of Pointing and Grasping in Humans [Elektronische Daten] [Scott T. Grafton, Andrew H. Fagg, Roger P. Woods, Michael A. Arbib] The functional anatomy of reaching and grasping simple objects was determined in nine healthy subjects with positron emission tomography imaging of regional cerebral blood flow (rCBF). In a prehension (grasping) task, subjects reached and grasped illuminated cylindrical objects with their right hand. In a pointing task, subjects reached and pointed over the same targets. In a control condition subjects looked at the targets. Both movement tasks increased activity in a distributed set of cortical and subcortical sites: contralateral motor, premotor, ventral supplementary motor area (SMA), cingulate, superior parietal, and dorsal occipital cortex. Cortical areas including cuneate and dorsal occipital cortex were more extensively activated than ventral occipital or temporal pathways. The left parietal operculum (putative SII) was recruited during grasping but not pointing. Blood flow changes were individually localized with respect to local cortical anatomy using sulcal landmarks. Consistent anatomic landmarks from MRI scans could be identified to locate sensorimotor, ventral SMA, and SII blood flow increases. The time required to complete individual movements and the amount of movement made during imaging correlated positively with the magnitude of rCBF increases during grasping in the contralateral inferior sensorimotor, cingulate, and ipsilateral inferior temporal cortex, and bilateral anterior cerebellum. This functional-anatomic study defines a cortical system for "pragmatic” manipulation of simple neutral objects. © 1996 Oxford University Press Articles nationallicence Grafton Scott T. USC PET Imaging Sciences Center, Department of Radiology, University of Southern California Los Angeles, California 90033 aut Fagg Andrew H. Center for Neural Engineering, University of Southern California Los Angeles, California 90033 aut Woods Roger P. Division of Brain Mapping, Department of Neurology, University of California at Los Angeles Los Angeles, California 90024 aut Arbib Michael A. Center for Neural Engineering, University of Southern California Los Angeles, California 90033 aut Cerebral Cortex Oxford University Press 6/2(1996-03), 226-237 1047-3211 6:2<226 1996 6 cercor https://doi.org/10.1093/cercor/6.2.226 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/cercor/6.2.226 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Grafton Scott T. USC PET Imaging Sciences Center, Department of Radiology, University of Southern California Los Angeles, California 90033 aut NATIONALLICENCE 700 1- Fagg Andrew H. Center for Neural Engineering, University of Southern California Los Angeles, California 90033 aut NATIONALLICENCE 700 1- Woods Roger P. Division of Brain Mapping, Department of Neurology, University of California at Los Angeles Los Angeles, California 90024 aut NATIONALLICENCE 700 1- Arbib Michael A. Center for Neural Engineering, University of Southern California Los Angeles, California 90033 aut NATIONALLICENCE 773 0- Cerebral Cortex Oxford University Press 6/2(1996-03), 226-237 1047-3211 6:2<226 1996 6 cercor Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford