caa a22 4500 397581610 CHVBK 20180308164908.0 cr unu---uuuuu 161202e199603 xx s 000 0 eng 10.1093/cercor/6.2.184 doi (NATIONALLICENCE)oxford-10.1093/cercor/6.2.184 Functional Development of the Corticocortical Pathway for Motion Analysis in the Macaque Monkey: A 14C-2-Deoxyglucose Study [Elektronische Daten] [C. Distler, J. Bachevalier, C. Kennedy, M. Mishkin, L. G. Ungerleider] The corticocortical pathway for motion analysis transmits visual information from striate cortex (V1) via V2. V3d, superior temporal sulcal areas MT, MST, and FST to motion-sensitive areas in the floor and upper bank of the anterior part of the superior temporal sulcus (AST). We studied the functional development of this pathway by applying the 14C-2-deoxyglucose method to rhesus monkeys (Macaca mulatta) ranging in age from 2 d to 3-4 years. A comparison of local cerebral glucose utilization (LCGU) in an intact and a visually deafferented hemisphere in each animal across the age range revealed that this pathway, immature at birth, reaches adult-like levels at 3 months of age. This developmental time course is reflected both in absolute LCGU and in the interhemispheric LCGU differences in all the areas of the pathway. At all ages, the interhemispheric difference in LCGU is largest in V1 and gradually declines along the pathway until a minimum is reached in AST. This decline likely reflects an increasing proportion of nonvisual inputs to the higher-order areas of the pathway. Measurements like those above taken in areas of inferior parietal cortex indicate that they mature at the same rate as those in the motion analysis pathway. However, comparison with findings on the functional development of the temporal areas of the occipitotemporal pathway for object vision (Bachevalier et al., 1991) suggests that areas along the motion analysis pathway and those in parietal cortex mature about 1 month earlier. © 1996 Oxford University Press Articles nationallicence Distler C. Laboratory of Neuropsychology, National Institute of Mental Health Bethesda, Maryland 20892 aut Bachevalier J. Laboratory of Neuropsychology, National Institute of Mental Health Bethesda, Maryland 20892 aut Kennedy C. Laboratory of Cerebral Metabolism, National Institute of Mental Health Bethesda, Maryland 20892 aut Mishkin M. Laboratory of Neuropsychology, National Institute of Mental Health Bethesda, Maryland 20892 aut Ungerleider L. G. Laboratory of Neuropsychology, National Institute of Mental Health Bethesda, Maryland 20892 aut Cerebral Cortex Oxford University Press 6/2(1996-03), 184-195 1047-3211 6:2<184 1996 6 cercor https://doi.org/10.1093/cercor/6.2.184 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/cercor/6.2.184 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Distler C. Laboratory of Neuropsychology, National Institute of Mental Health Bethesda, Maryland 20892 aut NATIONALLICENCE 700 1- Bachevalier J. Laboratory of Neuropsychology, National Institute of Mental Health Bethesda, Maryland 20892 aut NATIONALLICENCE 700 1- Kennedy C. Laboratory of Cerebral Metabolism, National Institute of Mental Health Bethesda, Maryland 20892 aut NATIONALLICENCE 700 1- Mishkin M. Laboratory of Neuropsychology, National Institute of Mental Health Bethesda, Maryland 20892 aut NATIONALLICENCE 700 1- Ungerleider L. G. Laboratory of Neuropsychology, National Institute of Mental Health Bethesda, Maryland 20892 aut NATIONALLICENCE 773 0- Cerebral Cortex Oxford University Press 6/2(1996-03), 184-195 1047-3211 6:2<184 1996 6 cercor Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford