caa a22 4500 397581637 CHVBK 20180308164908.0 cr unu---uuuuu 161202e199603 xx s 000 0 eng 10.1093/cercor/6.2.102 doi (NATIONALLICENCE)oxford-10.1093/cercor/6.2.102 Cortical Networks for Visual Reaching: Physiological and Anatomical Organization of Frontal and Parietal Lobe Arm Regions [Elektronische Daten] [Paul B. Johnson, Stefano Ferraina, Luigi Bianchi, Roberto Caminiti] The functional and structural properties of the dorsolateral frontal lobe and posterior parietal proximal arm representations were studied in macaque monkeys. Physiological mapping of primary motor (MI), dorsal premotor (PMd), and posterior parietal (area 5) cortices was performed in behaving monkeys trained in an instructed-delay reaching task. The parietofrontal corticocorticat connectivities of these same areas were subsequently examined anatomically by means of retrograde tracing techniques. Signal-, set-, movement-, and position-related directional neuronal activities were distributed nonuniformly within the task-related areas in both frontal and parietal cortices. Within the frontal lobe, moving caudally from PMd to the MI, the activity that signals for the visuospatial events leading to target localization decreased, while the activity more directly linked to movement generation increased. Physiological recordings in the superior parietal lobule revealed a gradient-like distribution of functional properties similar to that observed in the frontal lobe. Signal- and set-related activities were encountered more frequently in the intermediate and ventral part of the medial bank of the intraparietal sulcus (IPS), in area MIP. Movement- and position-related activities were distributed more uniformly within the superior parietal lobule (SPL), in both dorsal area 5 and in MIP. Frontal and parietal regions sharing similar functional properties were preferentially connected through their association pathways. As a result of this study, area MIP, and possibly areas MDP and 7m as well, emerge as the parietal nodes by which visual information may be relayed to the frontal lobe arm region. These parietal and frontal areas, along with their association connections, represent a potential cortical network for visual reaching. The architecture of this network is ideal for coding reaching as the result of a combination between visual and somatic information. © 1996 Oxford University Press Articles nationallicence Johnson Paul B. Department of Anatomy and Cell Biology University of North Carolina Chapel Hill, North Carolina 27599 aut Ferraina Stefano Istituto di Fisiologia umana, Università degli Studi di Roma "La Sapienza,” 00185 Rome, Italy aut Bianchi Luigi Istituto di Fisiologia umana, Università degli Studi di Roma "La Sapienza,” 00185 Rome, Italy aut Caminiti Roberto Istituto di Fisiologia umana, Università degli Studi di Roma "La Sapienza,” 00185 Rome, Italy aut Cerebral Cortex Oxford University Press 6/2(1996-03), 102-119 1047-3211 6:2<102 1996 6 cercor https://doi.org/10.1093/cercor/6.2.102 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/cercor/6.2.102 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Johnson Paul B. Department of Anatomy and Cell Biology University of North Carolina Chapel Hill, North Carolina 27599 aut NATIONALLICENCE 700 1- Ferraina Stefano Istituto di Fisiologia umana, Università degli Studi di Roma "La Sapienza,” 00185 Rome, Italy aut NATIONALLICENCE 700 1- Bianchi Luigi Istituto di Fisiologia umana, Università degli Studi di Roma "La Sapienza,” 00185 Rome, Italy aut NATIONALLICENCE 700 1- Caminiti Roberto Istituto di Fisiologia umana, Università degli Studi di Roma "La Sapienza,” 00185 Rome, Italy aut NATIONALLICENCE 773 0- Cerebral Cortex Oxford University Press 6/2(1996-03), 102-119 1047-3211 6:2<102 1996 6 cercor Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford