caa a22 4500 397581645 CHVBK 20180308164908.0 cr unu---uuuuu 161202e199603 xx s 000 0 eng 10.1093/cercor/6.2.156 doi (NATIONALLICENCE)oxford-10.1093/cercor/6.2.156 Functional Topography: Multidimensional Scaling and Functional Connectivity in the Brain [Elektronische Daten] [K. J. Friston, C. D. Frith, P. Fletcher, P. F. Liddle, R. S. J. Frackowiak] In neuroimaging, functional mapping usually implies mapping function into an anatomical space, for example, using statistical parametric mapping to identify activation foci, or the characterization of distributed changes with spatial modes (eigenimages or principal components) (Friston et al., 1993a). This article is about a complementary approach, namely, mapping anatomy into a functional space. We describe a simple variant of multidimensional scaling (principal coordinates analysis; Gower, 1966) that uses functional connectivity as its metric. The scaling transformation maps anatomy into a functional space. The topography, or proximity relationships, in this space embody the functional connectivity among brain regions. The higher the functional connectivity, the closer the regions. Functional connectivity is defined here as the correlation between remote neurophysiological events. The technique represents a descriptive characterization of anatomically distributed changes in the brain that reveals the structure of corticocortical interactions in terms of functional correlations. To illustrate the approach we have analyzed data from normal subjects and schizophrenic patients obtained with PET during the performance of word generation tasks. In particular, we focus on prefrontotemporal integration in normal subjects and show that, in schizophrenia, the left temporal regions and prefrontal cortex evidence abnormal functional connectivity. © 1996 Oxford University Press Articles nationallicence Friston K. J. Wellcome Department of Cognitive Neurology, Institute of Neurology, London, United Kingdom aut Frith C. D. Wellcome Department of Cognitive Neurology, Institute of Neurology, London, United Kingdom aut Fletcher P. Wellcome Department of Cognitive Neurology, Institute of Neurology, London, United Kingdom aut Liddle P. F. Wellcome Department of Cognitive Neurology, Institute of Neurology, London, United Kingdom aut Frackowiak R. S. J. Wellcome Department of Cognitive Neurology, Institute of Neurology, London, United Kingdom aut Cerebral Cortex Oxford University Press 6/2(1996-03), 156-164 1047-3211 6:2<156 1996 6 cercor https://doi.org/10.1093/cercor/6.2.156 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/cercor/6.2.156 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Friston K. J. Wellcome Department of Cognitive Neurology, Institute of Neurology, London, United Kingdom aut NATIONALLICENCE 700 1- Frith C. D. Wellcome Department of Cognitive Neurology, Institute of Neurology, London, United Kingdom aut NATIONALLICENCE 700 1- Fletcher P. Wellcome Department of Cognitive Neurology, Institute of Neurology, London, United Kingdom aut NATIONALLICENCE 700 1- Liddle P. F. Wellcome Department of Cognitive Neurology, Institute of Neurology, London, United Kingdom aut NATIONALLICENCE 700 1- Frackowiak R. S. J. Wellcome Department of Cognitive Neurology, Institute of Neurology, London, United Kingdom aut NATIONALLICENCE 773 0- Cerebral Cortex Oxford University Press 6/2(1996-03), 156-164 1047-3211 6:2<156 1996 6 cercor Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford