caa a22 4500 397581653 CHVBK 20180308164908.0 cr unu---uuuuu 161202e199603 xx s 000 0 eng 10.1093/cercor/6.2.288 doi (NATIONALLICENCE)oxford-10.1093/cercor/6.2.288 Deviant Auditory Stimuli Activate Human Left and Right Auditory Cortex Differently [Elektronische Daten] [Sari Levänen, Antti Ahonen, Riitta Hari, Linda McEvoy, Mikko Sams] Infrequent "deviant” auditory stimuli embedded in a homogeneous sequence of "standard” sounds evoke a neuromagnetic mismatch field (MMF), which is assumed to reflect automatic change detection in the brain. We investigated whether MMFs would reveal hemispheric differences in cortical auditory processing. Seven healthy adults were studied with a whole-scalp neuromagnetometer. The sound sequence, delivered to one ear at time, contained three infrequent deviants (differing from standards in duration, frequency, or interstimulus interval) intermixed with standard tones. MMFs peaked 9-34 msec earlier in the right than in the left hemisphere, irrespective of the stimulated ear. Whereas deviants activated only one MMF source in the left hemisphere, two temporally overlapping but spatially separate sources, one in the temporal lobe and another in the inferior parietal cortex, were necessary to explain the right-hemisphere MMFs. We suggest that the bilateral MMF components originating in the supratemporal cortex are feature specific whereas the right-hemisphere parietal component reflects more global auditory change detection. The results imply hemispheric differences in sound processing and suggest stronger involvement of the right than the left hemisphere in change detection. © 1996 Oxford University Press Articles nationallicence Levänen Sari Low Temperature Laboratory, Helsinki University of Technology 02150 Espoo, Finland aut Ahonen Antti Neuromag Ltd 00511 Helsinki, Finland aut Hari Riitta Low Temperature Laboratory, Helsinki University of Technology 02150 Espoo, Finland aut McEvoy Linda Low Temperature Laboratory, Helsinki University of Technology 02150 Espoo, Finland aut Sams Mikko Low Temperature Laboratory, Helsinki University of Technology 02150 Espoo, Finland aut Cerebral Cortex Oxford University Press 6/2(1996-03), 288-296 1047-3211 6:2<288 1996 6 cercor https://doi.org/10.1093/cercor/6.2.288 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/cercor/6.2.288 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Levänen Sari Low Temperature Laboratory, Helsinki University of Technology 02150 Espoo, Finland aut NATIONALLICENCE 700 1- Ahonen Antti Neuromag Ltd 00511 Helsinki, Finland aut NATIONALLICENCE 700 1- Hari Riitta Low Temperature Laboratory, Helsinki University of Technology 02150 Espoo, Finland aut NATIONALLICENCE 700 1- McEvoy Linda Low Temperature Laboratory, Helsinki University of Technology 02150 Espoo, Finland aut NATIONALLICENCE 700 1- Sams Mikko Low Temperature Laboratory, Helsinki University of Technology 02150 Espoo, Finland aut NATIONALLICENCE 773 0- Cerebral Cortex Oxford University Press 6/2(1996-03), 288-296 1047-3211 6:2<288 1996 6 cercor Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford