caa a22 4500 397581661 CHVBK 20180308164909.0 cr unu---uuuuu 161202e199603 xx s 000 0 eng 10.1093/cercor/6.2.120 doi (NATIONALLICENCE)oxford-10.1093/cercor/6.2.120 Suprathreshold Auditory Cortex Activation Visualized by Intrinsic Signal Optical Imaging [Elektronische Daten] [Jonathan S. Bakin, Michael C. Kwon, Susan A. Masino, Norman M. Weinberger, Ron D. Frostig] The suprathreshold tonotopic organization of rat and guinea pig auditory cortex was investigated using intrinsic signal optical imaging through a thinned skull. Optical imaging revealed that suprathreshold pure sine wave tone stimulation (25-40 dB) evoked activity over large cortical areas that were tonotopically organized. Three-dimensional surface plots of the activated areas revealed "patchy” auditory-evoked activity consisting of numerous local peaks and valleys building to a maximum. Subsequent detailed electrophysiological mapping in the same subjects confirmed the localization of auditory-evoked activity based on optical imaging, including responses to a test frequency at cortical loci more than 2 octaves away from the threshold-defined isofrequency contour. The success of this technique in visualizing auditory cortex functional organization at suprathreshold stimulus levels will allow for future investigations of auditory cortex frequency representation. including representational plasticity induced by a variety of experimental manipulations. © 1996 Oxford University Press Articles nationallicence Bakin Jonathan S. Center for the Neurobiology of Learning and Memory and Department of Psychobiology University of California, Irvine, California 92717 aut Kwon Michael C. Center for the Neurobiology of Learning and Memory and Department of Psychobiology University of California, Irvine, California 92717 aut Masino Susan A. Center for the Neurobiology of Learning and Memory and Department of Psychobiology University of California, Irvine, California 92717 aut Weinberger Norman M. Center for the Neurobiology of Learning and Memory and Department of Psychobiology University of California, Irvine, California 92717 aut Frostig Ron D. Center for the Neurobiology of Learning and Memory and Department of Psychobiology University of California, Irvine, California 92717 aut Cerebral Cortex Oxford University Press 6/2(1996-03), 120-130 1047-3211 6:2<120 1996 6 cercor https://doi.org/10.1093/cercor/6.2.120 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/cercor/6.2.120 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bakin Jonathan S. Center for the Neurobiology of Learning and Memory and Department of Psychobiology University of California, Irvine, California 92717 aut NATIONALLICENCE 700 1- Kwon Michael C. Center for the Neurobiology of Learning and Memory and Department of Psychobiology University of California, Irvine, California 92717 aut NATIONALLICENCE 700 1- Masino Susan A. Center for the Neurobiology of Learning and Memory and Department of Psychobiology University of California, Irvine, California 92717 aut NATIONALLICENCE 700 1- Weinberger Norman M. Center for the Neurobiology of Learning and Memory and Department of Psychobiology University of California, Irvine, California 92717 aut NATIONALLICENCE 700 1- Frostig Ron D. Center for the Neurobiology of Learning and Memory and Department of Psychobiology University of California, Irvine, California 92717 aut NATIONALLICENCE 773 0- Cerebral Cortex Oxford University Press 6/2(1996-03), 120-130 1047-3211 6:2<120 1996 6 cercor Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford