caa a22 4500 397581726 CHVBK 20180308164909.0 cr unu---uuuuu 161202e199603 xx s 000 0 eng 10.1093/cercor/6.2.165 doi (NATIONALLICENCE)oxford-10.1093/cercor/6.2.165 Systematic Regional Variations in the Loss of Cortical Cholinergic Fibers in Alzheimer's Disease [Elektronische Daten] [Changiz Geula, M.-Marsel Mesulam] The loss of cortical cholinergic fibers in Alzheimer's disease was investigated using choline acetyltransferase immunohistochemistry and acetylcholinesterase histochemistry. Within both the normal and Alzheimer's cerebral cortex, the two methods revealed an identical pattern of fiber staining. In the normal brain, cholinergic fiber density was highest in limbic and paralimbic cortical zones, intermediate in most sensory-motor and association zones, and lowest within the primary visual and visual association areas of the occipital lobe. In general, supragranular cortical layers contained a higher density of cholinergic fibers, and most of these were oriented vertically. In Alzheimer's disease, an overall 55% loss of cortical cholinergic fibers was detected. There was, however, marked regional variations in the extent of this loss in different cortical areas. Cortical areas within the temporal lobe, particularly the temporal association areas, displayed a dramatic loss of cholinergic fibers. By contrast, the anterior cingulate cortex, primary visual, primary somatosensory, and primary motor cortex displayed a relative preservation of cholinergic fibers. As a whole, greater loss of cholinergic fibers was detected in supragranular layers and in fibers oriented vertical to the cortical surface. These results indicate that cholinomimetic therapies are likely to have different effects on cholinergic transmission in various cortical areas. The precise mechanisms that lead to the regional variations in cortical cholinergic denervation in Alzheimer's disease remain to be elucidated. © 1996 Oxford University Press Articles nationallicence Geula Changiz Laboratory for Neurodegenerative and Aging Research, Department of Medicine, Harvard Medical School and Section of Geriatric Medicine, New England Deaconess Hospital Boston, Massachusetts 02215 aut Mesulam M.-Marsel Behavioral and Cognitive Neurology and Alzheimer Program, Department of Neurology Northwestern University Medical School Chicago, Illinois 60611 aut Cerebral Cortex Oxford University Press 6/2(1996-03), 165-177 1047-3211 6:2<165 1996 6 cercor https://doi.org/10.1093/cercor/6.2.165 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/cercor/6.2.165 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Geula Changiz Laboratory for Neurodegenerative and Aging Research, Department of Medicine, Harvard Medical School and Section of Geriatric Medicine, New England Deaconess Hospital Boston, Massachusetts 02215 aut NATIONALLICENCE 700 1- Mesulam M.-Marsel Behavioral and Cognitive Neurology and Alzheimer Program, Department of Neurology Northwestern University Medical School Chicago, Illinois 60611 aut NATIONALLICENCE 773 0- Cerebral Cortex Oxford University Press 6/2(1996-03), 165-177 1047-3211 6:2<165 1996 6 cercor Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford