caa a22 4500 397581912 CHVBK 20180308164909.0 cr unu---uuuuu 161202e199609 xx s 000 0 eng 10.1093/cercor/6.5.696 doi (NATIONALLICENCE)oxford-10.1093/cercor/6.5.696 Neocortical Ectopias in BXSB Mice: Effects upon Reference and Working Memory Systems [Elektronische Daten] [Gary W. Boehm, Gordon F. Sherman, Glenn D. Rosen, Albert M. Galaburda, Victor H. Denenberg] BXSB mice have an −40-60% incidence of neocortical ectopias in layer I of the prefrontal/motor cortex. Prior studies have found major behavioral differences between those with ectopias and their non-ectopic littermates. Some of these findings indicate that the two groups differ with respect to spatial reference and working memory. The purpose of this study was to measure reference and working memory in the same animals to test the hypothesis that the ectopics would have better reference memory but less effective working memory. The Lashley III maze has cul-de-sacs which must be eliminated, and T-choices where the animal has to decide whether to go left or right. Ectopic and non-ectopic mice were equally able to learn the maze and did not differ on cul-entry or T-choice errors. Then the maze was inverted and the animals were retested. Turning the maze upside down did not change the relative status of the blind alleys. Therefore, the reference memory knowledge from the prior week's training could be used to avoid entering the culs. However, inverting the maze caused a left-right mirror image reversal of the T-choices. Therefore, prior reference memory information would interfere with learning the new path through the maze, whereas working memory would enable the mouse to eliminate T-choice errors. Ectopic mice made less cul-entry errors and more T-choice errors than their non-ectopic littermates, as predicted. © 1996 Oxford University Press Articles nationallicence Boehm Gary W. Biobehavioral Sciences Graduate Degree Program, University of Connecticut, Storrs, CT 06269, Boston, MA 02215, USA aut Sherman Gordon F. Department of Neurology, Beth Israel Hospital and Harvard Medical School Boston, MA 02215, USA aut Rosen Glenn D. Department of Neurology, Beth Israel Hospital and Harvard Medical School Boston, MA 02215, USA aut Galaburda Albert M. Department of Neurology, Beth Israel Hospital and Harvard Medical School Boston, MA 02215, USA aut Denenberg Victor H. Biobehavioral Sciences Graduate Degree Program, University of Connecticut, Storrs, CT 06269, Boston, MA 02215, USA aut Cerebral Cortex Oxford University Press 6/5(1996-09), 696-700 1047-3211 6:5<696 1996 6 cercor https://doi.org/10.1093/cercor/6.5.696 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/cercor/6.5.696 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Boehm Gary W. Biobehavioral Sciences Graduate Degree Program, University of Connecticut, Storrs, CT 06269, Boston, MA 02215, USA aut NATIONALLICENCE 700 1- Sherman Gordon F. Department of Neurology, Beth Israel Hospital and Harvard Medical School Boston, MA 02215, USA aut NATIONALLICENCE 700 1- Rosen Glenn D. Department of Neurology, Beth Israel Hospital and Harvard Medical School Boston, MA 02215, USA aut NATIONALLICENCE 700 1- Galaburda Albert M. Department of Neurology, Beth Israel Hospital and Harvard Medical School Boston, MA 02215, USA aut NATIONALLICENCE 700 1- Denenberg Victor H. Biobehavioral Sciences Graduate Degree Program, University of Connecticut, Storrs, CT 06269, Boston, MA 02215, USA aut NATIONALLICENCE 773 0- Cerebral Cortex Oxford University Press 6/5(1996-09), 696-700 1047-3211 6:5<696 1996 6 cercor Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford