caa a22 4500 397581971 CHVBK 20180308164909.0 cr unu---uuuuu 161202e199607 xx s 000 0 eng 10.1093/cercor/6.4.620 doi (NATIONALLICENCE)oxford-10.1093/cercor/6.4.620 Prenatal Development of Parvalbumin Immunoreactivity in the Human Striate Cortex [Elektronische Daten] [Q. L. Cao, X. X. Yan, X. G. Luo, L. J. Garey] In human primary visual cortex, parvalbumin (PV) is expressed by Cajal-Retzius cells in layer I by 20 weeks of gestation (20W), but its immunoreactivity is mostly lost by term. PV immunoreactivity in layers II-VI mainly develops later, from 26 to 34W, following an approximately ‘inside-outside' sequence in a series of bands. PV-positive perikarya appear in layer V by 20W, but only in small numbers. They increase in number and staining intensity by 26W. By 30W a band of densely labelled somata and neuropil occupies layers IVC-VI. By 34W a second, less dense, band of cell bodies and neuropil appears in IVB and IVCα, separated from the deep band by IVCβ which is cell-sparse and almost fibre-free. Between 38 and 40W, a third minor band consisting mainly of fibres is seen in layer IVA. Reactive cell bodies form clusters, and the neuropil staining is mosaic-like. PV-positive neurons are of two main types: large with a wide dendritic arbor, and smaller with simpler dendrites. However, a few have characteristics of pyramidal cells, and a few others resemble glial cells. The laminar pattern of PV-immunoreactive somata in human striate cortex is established by term, rather than postnatally as in most mammals, implying that PV may be involved in neuronal development in prenatal human striate cortex. © 1996 Oxford University Press Articles nationallicence Cao Q. L. Department of Anatomy and Neurobiology, Hunan Medical University Changsha, Hunan 410078, People's Republic of China aut Yan X. X. Department of Anatomy and Neurobiology, Hunan Medical University Changsha, Hunan 410078, People's Republic of China aut Luo X. G. Department of Anatomy and Neurobiology, Hunan Medical University Changsha, Hunan 410078, People's Republic of China aut Garey L. J. Department of Anatomy, Charing Cross and Westminster Medical School London W6 8RF, UK aut Cerebral Cortex Oxford University Press 6/4(1996-07), 620-630 1047-3211 6:4<620 1996 6 cercor https://doi.org/10.1093/cercor/6.4.620 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/cercor/6.4.620 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cao Q. L. Department of Anatomy and Neurobiology, Hunan Medical University Changsha, Hunan 410078, People's Republic of China aut NATIONALLICENCE 700 1- Yan X. X. Department of Anatomy and Neurobiology, Hunan Medical University Changsha, Hunan 410078, People's Republic of China aut NATIONALLICENCE 700 1- Luo X. G. Department of Anatomy and Neurobiology, Hunan Medical University Changsha, Hunan 410078, People's Republic of China aut NATIONALLICENCE 700 1- Garey L. J. Department of Anatomy, Charing Cross and Westminster Medical School London W6 8RF, UK aut NATIONALLICENCE 773 0- Cerebral Cortex Oxford University Press 6/4(1996-07), 620-630 1047-3211 6:4<620 1996 6 cercor Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford