caa a22 4500 397581998 CHVBK 20180308164909.0 cr unu---uuuuu 161202e199607 xx s 000 0 eng 10.1093/cercor/6.4.551 doi (NATIONALLICENCE)oxford-10.1093/cercor/6.4.551 Quantitative Magnetic Resonance Imaging of Human Brain Development: Ages 4-18 [Elektronische Daten] [Jay N. Giedd, John W. Snell, Nicholas Lange, Jagath C. Rajapakse, B. J. Casey, Patricia L. Kozuch, A. Catherine Vaituzis, Yolanda C. Vauss, Susan D. Hamburger, Debra Kaysen, Judith L. Rapoport] Brain magnetic resonance images (MRI) of 104 healthy children and adolescents, aged 4-18, showed significant effects of age and gender on brain morphometry. Males had larger cerebral (9%) and cerebellar (8%) volumes (P < 0.0001 and P = 0.008. respectively), which remained significant even after correction for height and weight After adjusting for cerebral size, the putamen and globus pallidus remained larger in males, while relative caudate size was larger in females. Neither cerebral nor cerebellar volume changed significantly across this age range. Lateral ventricular volume increased significantly in males (trend for females), with males showing an increase in slope after age 11. In males only, caudate and putamen decreased with age (P = 0.007 and 0.05, respectively). The left lateral ventricles and putamen were significantly greater than the right P = 0.01 and 0.0001, respectively). In contrast, the cerebral hemispheres and caudate showed a highly consistent right greater-than-left asymmetry (P < 0.0001 for both). All volumes demonstrated a high degree of variability. These findings highlight gender-specific maturational changes of the developing brain and the need for large gender-matched samples in pediatric neuropsychiatric studies. © 1996 Oxford University Press Articles nationallicence Giedd Jay N. National Institute of Mental Health, Child Psychiatry Branch Bethesda, MD 20892-1600 aut Snell John W. University of Virginia, Department of Neurosurgery VA aut Lange Nicholas National Institute of Neurological Disorders and Stroke Bethesda, MD, USA aut Rajapakse Jagath C. National Institute of Mental Health, Child Psychiatry Branch Bethesda, MD 20892-1600 aut Casey B. J. National Institute of Mental Health, Child Psychiatry Branch Bethesda, MD 20892-1600 aut Kozuch Patricia L. National Institute of Mental Health, Child Psychiatry Branch Bethesda, MD 20892-1600 aut Vaituzis A. Catherine National Institute of Mental Health, Child Psychiatry Branch Bethesda, MD 20892-1600 aut Vauss Yolanda C. National Institute of Mental Health, Child Psychiatry Branch Bethesda, MD 20892-1600 aut Hamburger Susan D. National Institute of Mental Health, Child Psychiatry Branch Bethesda, MD 20892-1600 aut Kaysen Debra National Institute of Mental Health, Child Psychiatry Branch Bethesda, MD 20892-1600 aut Rapoport Judith L. National Institute of Mental Health, Child Psychiatry Branch Bethesda, MD 20892-1600 aut Cerebral Cortex Oxford University Press 6/4(1996-07), 551-559 1047-3211 6:4<551 1996 6 cercor https://doi.org/10.1093/cercor/6.4.551 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/cercor/6.4.551 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Giedd Jay N. National Institute of Mental Health, Child Psychiatry Branch Bethesda, MD 20892-1600 aut NATIONALLICENCE 700 1- Snell John W. University of Virginia, Department of Neurosurgery VA aut NATIONALLICENCE 700 1- Lange Nicholas National Institute of Neurological Disorders and Stroke Bethesda, MD, USA aut NATIONALLICENCE 700 1- Rajapakse Jagath C. National Institute of Mental Health, Child Psychiatry Branch Bethesda, MD 20892-1600 aut NATIONALLICENCE 700 1- Casey B. J. National Institute of Mental Health, Child Psychiatry Branch Bethesda, MD 20892-1600 aut NATIONALLICENCE 700 1- Kozuch Patricia L. National Institute of Mental Health, Child Psychiatry Branch Bethesda, MD 20892-1600 aut NATIONALLICENCE 700 1- Vaituzis A. Catherine National Institute of Mental Health, Child Psychiatry Branch Bethesda, MD 20892-1600 aut NATIONALLICENCE 700 1- Vauss Yolanda C. National Institute of Mental Health, Child Psychiatry Branch Bethesda, MD 20892-1600 aut NATIONALLICENCE 700 1- Hamburger Susan D. National Institute of Mental Health, Child Psychiatry Branch Bethesda, MD 20892-1600 aut NATIONALLICENCE 700 1- Kaysen Debra National Institute of Mental Health, Child Psychiatry Branch Bethesda, MD 20892-1600 aut NATIONALLICENCE 700 1- Rapoport Judith L. National Institute of Mental Health, Child Psychiatry Branch Bethesda, MD 20892-1600 aut NATIONALLICENCE 773 0- Cerebral Cortex Oxford University Press 6/4(1996-07), 551-559 1047-3211 6:4<551 1996 6 cercor Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford