caa a22 4500 397582005 CHVBK 20180308164910.0 cr unu---uuuuu 161202e199607 xx s 000 0 eng 10.1093/cercor/6.4.600 doi (NATIONALLICENCE)oxford-10.1093/cercor/6.4.600 Activation of Human Prefrontal Cortex during Spatial and Nonspatial Working Memory Tasks Measured by Functional MRI [Elektronische Daten] [Gregory McCarthy, Aina Puce, Todd Constable, John H. Krystal, John C. Gore, Patricia Goldman-Rakic] Separate working memory domains for spatial location, and for objects, faces, and patterns, have been identified in the prefrontal cortex (PFC) of nonhuman primates. We have used functional magnetic resonance imaging to examine whether spatial and nonspatial visual working memory processes are similarly dissociable in human PFC. Subjects performed tasks which required them to remember either the location or shape of successive visual stimuli. We found that the mnemonic component of the working memory tasks affected the hemispheric pattern of PFC activation. The spatial (LOCATION) working memory task preferentially activated the middle frontal gyrus (MFG) in the right hemisphere, while the nonspatial (SHAPE) working memory task activated the NIFG in both hemispheres. Furthermore, the area of activation in the left hemisphere extended into the inferior frontal gyrus for the nonspatial SHAPE task. A perceptual target (DOT) detection task also activated the MFG bilaterally, but at a level approximately half that of the working memory tasks. The activation in the MFG occurred within 3-6 s of task onset and declined following task offset. Time-course analysis revealed a different pattern for the cingulate gyrus, in which activation occurred upon task completion. Cingulate activation was greatest following the SHAPE task and was greater in the left hemisphere. The present results support the prominent role of the PFC and, specifically, the MFG in working memory, and indicate that the mnemonic content of the task affects the relative weighting of hemispheric activation. © 1996 Oxford University Press Articles nationallicence McCarthy Gregory Neuropsychology Laboratory, VA Medical Center West Haven, CT 06516 aut Puce Aina Neuropsychology Laboratory, VA Medical Center West Haven, CT 06516 aut Constable Todd Departments of Diagnostic Radiology, Yale University School of Medicine New Haven, CT 06510, USA aut Krystal John H. Departments of Psychiatry, Yale University School of Medicine New Haven, CT 06510, USA aut Gore John C. Departments of Diagnostic Radiology, Yale University School of Medicine New Haven, CT 06510, USA aut Goldman-Rakic Patricia Departments of Neurobiology, Yale University School of Medicine New Haven, CT 06510, USA aut Cerebral Cortex Oxford University Press 6/4(1996-07), 600-611 1047-3211 6:4<600 1996 6 cercor https://doi.org/10.1093/cercor/6.4.600 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/cercor/6.4.600 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- McCarthy Gregory Neuropsychology Laboratory, VA Medical Center West Haven, CT 06516 aut NATIONALLICENCE 700 1- Puce Aina Neuropsychology Laboratory, VA Medical Center West Haven, CT 06516 aut NATIONALLICENCE 700 1- Constable Todd Departments of Diagnostic Radiology, Yale University School of Medicine New Haven, CT 06510, USA aut NATIONALLICENCE 700 1- Krystal John H. Departments of Psychiatry, Yale University School of Medicine New Haven, CT 06510, USA aut NATIONALLICENCE 700 1- Gore John C. Departments of Diagnostic Radiology, Yale University School of Medicine New Haven, CT 06510, USA aut NATIONALLICENCE 700 1- Goldman-Rakic Patricia Departments of Neurobiology, Yale University School of Medicine New Haven, CT 06510, USA aut NATIONALLICENCE 773 0- Cerebral Cortex Oxford University Press 6/4(1996-07), 600-611 1047-3211 6:4<600 1996 6 cercor Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford