caa a22 4500 397582048 CHVBK 20180308164910.0 cr unu---uuuuu 161202e199605 xx s 000 0 eng 10.1093/cercor/6.3.506 doi (NATIONALLICENCE)oxford-10.1093/cercor/6.3.506 Short-Lasting Classical Conditioning Induces Reversible Changes of Representational Maps of Vibrissae in Mouse SI Cortex—A 2DG Study [Elektronische Daten] [E. Siucinska, M. Kossut] It has been known for several years that receptive field properties of sensory cortical neurons can be altered by learning experiences. We attempted to visualize a global change of the cortical body map induced by learning. In order to do this a short-duration classical conditioning involving stimulation of a row of mystacial vibrissae in mice was followed with 2-deoxyglucose (2DG) mapping of functional activity. Three conditioning sessions that paired stimulation of a row of whiskers with a tail shock produced an increase of the functional representation in somatosensory cortex (SI) of a row of the whiskers stimulated during the training. This plastic change of vibrissal representation in SI was visualized with 2DG autoradiography a day after completion of training. The expansion of representation was the most pronounced in cortical layer IV, and to a lesser extent, in layer IIIb. The expansion was observed in conditioned but not in pseudoconditioned mice or in animals that received only the conditioned stimulus. If training was discontinued, the enlargement of vibrissal representation progressively faded. The reversal could be accelerated by a behavioral extinction procedure. This study gives the pictorial demonstration of rapid, transient, and extinguishable learning-dependent changes in SI cortical maps. © 1996 Oxford University Press Article nationallicence Siucinska E. Department of Neurophysiology, Nencki Institute, 02-093 Warsaw, Poland aut Kossut M. Department of Neurophysiology, Nencki Institute, 02-093 Warsaw, Poland aut Cerebral Cortex Oxford University Press 6/3(1996-05), 506-513 1047-3211 6:3<506 1996 6 cercor https://doi.org/10.1093/cercor/6.3.506 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/cercor/6.3.506 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Siucinska E. Department of Neurophysiology, Nencki Institute, 02-093 Warsaw, Poland aut NATIONALLICENCE 700 1- Kossut M. Department of Neurophysiology, Nencki Institute, 02-093 Warsaw, Poland aut NATIONALLICENCE 773 0- Cerebral Cortex Oxford University Press 6/3(1996-05), 506-513 1047-3211 6:3<506 1996 6 cercor Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford