caa a22 4500 397582064 CHVBK 20180308164910.0 cr unu---uuuuu 161202e199605 xx s 000 0 eng 10.1093/cercor/6.3.406 doi (NATIONALLICENCE)oxford-10.1093/cercor/6.3.406 Functional Significance of Long-Term Potentiation for Sequence Learning and Prediction [Elektronische Daten] [L. F Abbott, Kenneth I. Blum] Population coding, where neurons with broad and overlapping firing rate tuning curves collectively encode information about a stimulus, is a common feature of sensory systems. We use decoding methods and measured properties of NMDA-mediated LTP induction to study the impact of long-term potentiation of synapses between the neurons of such a coding array. We find that, due to a temporal asymmetry in the induction of NMDA-mediated LTP, firing patterns in a neuronal array that initially represent the current value of a sensory input will, after training, provide an experienced-based prediction of that input instead. We compute how this prediction arises from and depends on the training experience. We also show how the encoded prediction can be used to generate learned motor sequences, such as the movement of a limb. This involves a novel form of memory recall that is driven by the motor response so that it automatically generates new information at a rate appropriate for the task being performed. © 1996 Oxford University Press Article nationallicence Abbott L. F. Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02254 aut Blum Kenneth I. Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02254 aut Cerebral Cortex Oxford University Press 6/3(1996-05), 406-416 1047-3211 6:3<406 1996 6 cercor https://doi.org/10.1093/cercor/6.3.406 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/cercor/6.3.406 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Abbott L. F. Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02254 aut NATIONALLICENCE 700 1- Blum Kenneth I. Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02254 aut NATIONALLICENCE 773 0- Cerebral Cortex Oxford University Press 6/3(1996-05), 406-416 1047-3211 6:3<406 1996 6 cercor Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford