caa a22 4500 39758220X CHVBK 20180308164910.0 cr unu---uuuuu 161202e199605 xx s 000 0 eng 10.1093/cercor/6.3.540 doi (NATIONALLICENCE)oxford-10.1093/cercor/6.3.540 Complementary Distribution of Collagen Type IV and the Epidermal Growth Factor Receptor in the Rat Embryonic Telencephalon [Elektronische Daten] [Kathie L. Eagleson, Raymond T. Ferri, Pat Levitt] We previously identified an interaction between collagen type IV and the EGF receptor that regulates the differentiation of a limbic cortical phenotype in vitro (ferri and Levitt, 1995). In the present study, we map the expression of the EGF receptor and collagen type IV in the embryonic telencephalon of the rat. At embryonic day (E) 11, the earliest age examined, both proteins are coexpressed throughout the ventricular zone in the cerebral wall; this zone remains immunoreactive throughout corticogenesis (E14-E19). The cells comprising the subventricular zone are the most intensely immunoreactive for the EGF receptor, although little collagen type IV is detected in this region. In contrast, postmitotic neurons that leave the proliferative zones are negative for the receptor. Moreover, during the peak of neuronal migration, the intermediate zone lacks collagen type IV immunoreactivity. Neurons that settle in the cortical plate once again exhibit EGF receptor immunoreactivity; this same zone is devoid of collagen type IV. By E19, coexpression of both proteins is evident only in the rostral extension of the subventricular zone, the pathway of migrating cells leading to the olfactory bulb. The temporal and spatial overlap of the EGE receptor and collagen type IV in the cortical progenitor pool in vivo indicates that these molecules may participate in the initial decisions of neuronal differentiation. Their modified distribution during cortical maturation suggests a changing role for both proteins. © 1996 Oxford University Press Article nationallicence Eagleson Kathie L. Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School-UMDNJ Piscataway, New Jersey 08854 aut Ferri Raymond T. Department of Anatomy and Neurobiology, Medical College of Pennsylvania Philadelphia, Pennsylvania 19129 aut Levitt Pat Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School-UMDNJ Piscataway, New Jersey 08854 aut Cerebral Cortex Oxford University Press 6/3(1996-05), 540-549 1047-3211 6:3<540 1996 6 cercor https://doi.org/10.1093/cercor/6.3.540 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/cercor/6.3.540 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Eagleson Kathie L. Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School-UMDNJ Piscataway, New Jersey 08854 aut NATIONALLICENCE 700 1- Ferri Raymond T. Department of Anatomy and Neurobiology, Medical College of Pennsylvania Philadelphia, Pennsylvania 19129 aut NATIONALLICENCE 700 1- Levitt Pat Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School-UMDNJ Piscataway, New Jersey 08854 aut NATIONALLICENCE 773 0- Cerebral Cortex Oxford University Press 6/3(1996-05), 540-549 1047-3211 6:3<540 1996 6 cercor Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford