caa a22 4500 397590326 CHVBK 20180308164936.0 cr unu---uuuuu 161202e199603 xx s 000 0 eng 10.1093/jac/37.3.403 doi (NATIONALLICENCE)oxford-10.1093/jac/37.3.403 Antiviral resistance: mechanisms, clinical significance, and future implications [Elektronische Daten] [David W. Kimberlin, Richard J. Whitley] The increased awareness of antiviral resistance over the past decade has paralleled the development of new antiviral agents. While such resistant viral isolates are of clinical significance primarily in immunocompromised individuals, the development and transmission of such mutants have been reported in immunocompetent persons as well. As antiviral agents are increasingly utilised by the clinician, the incidence of such occurrences is likely to increase. Issues relating to mechanisms of antiviral resistance, clinical manifestations and significance of resistance, and implications for future antiviral development and utilisation are reviewed in this article. Viruses that are discussed include herpes simplex virus, varicella-zoster virus, cytomegalovinis, influenza A virus, and human immunodeficiency virus. © 1996 The British Society for Antimicrobial Chemotherapy Review nationallicence Kimberlin David W. Department of Pediatrics, The University of Alabama at Birmingham, 1600 Seventh Avenue South, Suite 616, Birmingham, AL 35233, USA aut Whitley Richard J. Department of Pediatrics, The University of Alabama at Birmingham, 1600 Seventh Avenue South, Suite 616, Birmingham, AL 35233, USA aut Journal of Antimicrobial Chemotherapy Oxford University Press 37/3(1996-03), 403-421 0305-7453 37:3<403 1996 37 jac https://doi.org/10.1093/jac/37.3.403 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/37.3.403 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kimberlin David W. Department of Pediatrics, The University of Alabama at Birmingham, 1600 Seventh Avenue South, Suite 616, Birmingham, AL 35233, USA aut NATIONALLICENCE 700 1- Whitley Richard J. Department of Pediatrics, The University of Alabama at Birmingham, 1600 Seventh Avenue South, Suite 616, Birmingham, AL 35233, USA aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 37/3(1996-03), 403-421 0305-7453 37:3<403 1996 37 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford