caa a22 4500 397590350 CHVBK 20180308164936.0 cr unu---uuuuu 161202e199608 xx s 000 0 eng 10.1093/jac/38.2.245 doi (NATIONALLICENCE)oxford-10.1093/jac/38.2.245 Clark Richard B. Department of Microbiology, American Medical Laboratories, Inc., P.O. Box 10841, Chantilly, VA 22021, USA Imipenem resistance among Acinetobacter baumannii: association with reduced expression of a 33-36 kDa outer membrane protein [Elektronische Daten] [Richard B. Clark] The mechanism of imipenem resistance of two Acinetobacter baumannii isolates (A-1 and A-24) was characterized in this study. A spontaneous revertant (A-1 (rev)) derived from isolate A-1 showed susceptibility to imipenem. β-Lactamase hydrolysis studies showed no evidence of an imipenem hydrolyzing enzyme among A-1, A-24, A-1 (rev), or two other imipenem susceptible A. baumannii isolates. Outer membrane protein (OMP) analysis indicated decreased expression of a 33-36 kDa protein by isolates A-1 and A-24 when compared with A-1 (rev) and the other A. bawnannii isolates. In conclusion, decreased expression of a 33-36 kDa OMP is associated with imipenem resistance among A. buumannii. © 1996 by the British Society for Antimicrobial Chemotherapy Brief reports nationallicence Journal of Antimicrobial Chemotherapy Oxford University Press 38/2(1996-08), 245-251 0305-7453 38:2<245 1996 38 jac https://doi.org/10.1093/jac/38.2.245 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/38.2.245 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Clark Richard B. Department of Microbiology, American Medical Laboratories, Inc., P.O. Box 10841, Chantilly, VA 22021, USA NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 38/2(1996-08), 245-251 0305-7453 38:2<245 1996 38 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford