caa a22 4500 397590369 CHVBK 20180308164936.0 cr unu---uuuuu 161202e199611 xx s 000 0 eng 10.1093/jac/38.5.829 doi (NATIONALLICENCE)oxford-10.1093/jac/38.5.829 Sequential antibiotic therapy for acne promotes the carriage of resistant staphylococci on the skin of contacts [Elektronische Daten] [Yvonne W. Miller, E. Anne Eady, Richard W. Lacey, Jonathan H. Cove, Derrick N. Joanes, William J. Cunliffe] The selection of a predominantly resistant staphylococcal skin flora in acne patients during antibiotic treatment has been extensively documented. This study sought to determine whether antibiotic therapy for acne had any effect on skin carriage of resistant coagulase-negative staphylococci (CNS) by close contacts of treated patients. Bacterial samples were obtained using a scrub wash technique from facial skin of 41 contacts (parents, siblings or partners) of patients who had been treated with at least three different antibiotics over a minimum period of 2 years. Samples were also obtained from 41 control subjects who had no known contact with any antibiotic treated acne patient. None of the contacts or controls had received any antibiotic therapy in the preceding two years. The number, percentage and prevalence of CNS resistant to each of seven antibiotics was estimated by plating serial ten-fold dilutions of wash fluid directly onto antibiotic-containing and antibiotic-free medium. Significantly more contacts than controls carried strains resistant to erythromycin, clindamycin, fusidic acid, trimethoprim and chloramphenicol as well as more multiply resistant strains (P<0.05, x2)- The number and percentage of staphylococci resistant to tetracycline, erythromycin, clindamycin, fusidic acid and chloramphenicol were also significantly raised (P<0.05, Mann-Whitney U-test) in contacts. Only aminoglycoside resistance was not increased by any of the above criteria. These observations provide evidence that sequential antibiotic therapy for acne exerts selective pressure for increased skin carriage of resistant CNS not only in patients but also in their close contacts. © 1996 by the British Society for Antimicrobial Chemotherapy Original articles nationallicence Miller Yvonne W. Departments of Microbiology, University of Leeds Leeds LS2 9JT Eady E. Anne Departments of Microbiology, University of Leeds Leeds LS2 9JT aut Lacey Richard W. Department of Microbiology, Chapel Allerton Hospital Chapeltown Road, Leeds LS7 4SA aut Cove Jonathan H. Departments of Microbiology, University of Leeds Leeds LS2 9JT aut Joanes Derrick N. Statistics, University of Leeds Leeds LS2 9JT aut Cunliffe William J. Department of Dermatology, Leeds General Infirmary Leeds LSI 3EX, UK aut Journal of Antimicrobial Chemotherapy Oxford University Press 38/5(1996-11), 829-837 0305-7453 38:5<829 1996 38 jac https://doi.org/10.1093/jac/38.5.829 text/html Onlinezugriff via DOI 1 other jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/38.5.829 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Miller Yvonne W. Departments of Microbiology, University of Leeds Leeds LS2 9JT NATIONALLICENCE 700 1- Eady E. Anne Departments of Microbiology, University of Leeds Leeds LS2 9JT aut NATIONALLICENCE 700 1- Lacey Richard W. Department of Microbiology, Chapel Allerton Hospital Chapeltown Road, Leeds LS7 4SA aut NATIONALLICENCE 700 1- Cove Jonathan H. Departments of Microbiology, University of Leeds Leeds LS2 9JT aut NATIONALLICENCE 700 1- Joanes Derrick N. Statistics, University of Leeds Leeds LS2 9JT aut NATIONALLICENCE 700 1- Cunliffe William J. Department of Dermatology, Leeds General Infirmary Leeds LSI 3EX, UK aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 38/5(1996-11), 829-837 0305-7453 38:5<829 1996 38 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford