caa a22 4500 397590393 CHVBK 20180308164936.0 cr unu---uuuuu 161202e199607 xx s 000 0 eng 10.1093/jac/38.1.59 doi (NATIONALLICENCE)oxford-10.1093/jac/38.1.59 Comparative in-vitro activity of cefaclor against urinary tract isolates of Escherichia coli [Elektronische Daten] [C. A. Webster, R. Curran, K. J. Towner] Insusceptibility levels of cefaclor and other commonly prescribed antibiotics were determined for 489 consecutive hospital and community-associated urinary tract isolates of Escherichia coli from the Nottingham area of the UK. Significant resistance (MIC of ≥ mg/L) to cefaclor was found to be uncommon in the UK, with insusceptibility percentages as low as 1.5% and 1.4% amongst hospital and community isolates, respectively. When compared with other antimicrobials used commonly for treating urinary tract infection, only ciprofloxacin showed greater activity, though cefaclor showed significantly greater in-vitro activity than cephalexin, ampicillin and trimethoprim. Only seven isolates were insusceptible to cefaclor at a concentration of 8 mg/L. Each of these isolates produced a βlactamase, but it is unlikely that β-lactamase production was the sole reason for insusceptibility since these isolates were also insusceptible to co-amoxiclav. Cefaclor compared extremely well with co-amoxiclav against ampicillin-insusceptible isolates, with none of the pharmacokinetic difficulties and considerations associated with the use of β-lactam:β-lactamase inhibitor combinations. Cefaclor appears to be a useful cost-effective alternative to current therapeutic options, particularly for long-term low-dose treatment of recurrent urinary tract infection in those geographical areas where the likelihood of resistance to other possible agents is becoming unacceptably high. © 1996 by the British Society for Antimicrobial Chemotherapy Original articles nationallicence Webster C. A. Department of Microbiology & PHLS Laboratory, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH, UK aut Curran R. Department of Microbiology & PHLS Laboratory, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH, UK aut Towner K. J. Department of Microbiology & PHLS Laboratory, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH, UK aut Journal of Antimicrobial Chemotherapy Oxford University Press 38/1(1996-07), 59-66 0305-7453 38:1<59 1996 38 jac https://doi.org/10.1093/jac/38.1.59 text/html Onlinezugriff via DOI 1 other jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/38.1.59 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Webster C. A. Department of Microbiology & PHLS Laboratory, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH, UK aut NATIONALLICENCE 700 1- Curran R. Department of Microbiology & PHLS Laboratory, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH, UK aut NATIONALLICENCE 700 1- Towner K. J. Department of Microbiology & PHLS Laboratory, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH, UK aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 38/1(1996-07), 59-66 0305-7453 38:1<59 1996 38 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford