caa a22 4500 397590466 CHVBK 20180308164937.0 cr unu---uuuuu 161202e199605 xx s 000 0 eng 10.1093/jac/37.5.987 doi (NATIONALLICENCE)oxford-10.1093/jac/37.5.987 Interaction of macrolides with adornase during DNA hydrolysis [Elektronische Daten] [Laurent Ripoll, Philippe Reinert, Louis-Ferdinand Pépin, Philippe H. Lagrange] Since patients with cystic fibrosis are often treated with adornase to reduce sputum viscosity, and because of preliminary reports of efficacy of long-term low-dose erythromycin therapy in chronic airway diseases, it is likely that adornase and macrolides might be given together in such patients. A possible interaction between these drugs was therefore investigated. Using hyperchromic effect to quantify adornase activity, a time- and dose-dependent inhibitory effect on human DNA hydrolysis has been observed for erythromycin, roxithromycin and azithromycin. Inhibitory doses 50% for adornase were graphically determined. Azithromycin exhibited the strongest inhibitory effect. © 1996 The British Society for Antimicrobial Chemotherapy Brief reports nationallicence Ripoll Laurent Laboratoire de Microbiologie, Hôpital Saint-Louis I avenue Claude Vellefaux, 75010 Paris, France aut Reinert Philippe Service de Pediatrie, Centre Hospitalier Inter communal 40 avenue de Verdun, 94010 Creteil, France aut Pépin Louis-Ferdinand Pfizer, 86 rue de Paris, 91407 Orsay, France aut Lagrange Philippe H. Laboratoire de Microbiologie, Hôpital Saint-Louis I avenue Claude Vellefaux, 75010 Paris, France aut Journal of Antimicrobial Chemotherapy Oxford University Press 37/5(1996-05), 987-991 0305-7453 37:5<987 1996 37 jac https://doi.org/10.1093/jac/37.5.987 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/37.5.987 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ripoll Laurent Laboratoire de Microbiologie, Hôpital Saint-Louis I avenue Claude Vellefaux, 75010 Paris, France aut NATIONALLICENCE 700 1- Reinert Philippe Service de Pediatrie, Centre Hospitalier Inter communal 40 avenue de Verdun, 94010 Creteil, France aut NATIONALLICENCE 700 1- Pépin Louis-Ferdinand Pfizer, 86 rue de Paris, 91407 Orsay, France aut NATIONALLICENCE 700 1- Lagrange Philippe H. Laboratoire de Microbiologie, Hôpital Saint-Louis I avenue Claude Vellefaux, 75010 Paris, France aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 37/5(1996-05), 987-991 0305-7453 37:5<987 1996 37 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford