caa a22 4500 397590490 CHVBK 20180308164937.0 cr unu---uuuuu 161202e199603 xx s 000 0 eng 10.1093/jac/37.3.511 doi (NATIONALLICENCE)oxford-10.1093/jac/37.3.511 Activity of pyronaridine and mepacrine against twelve strains of Plasmodium falciparum in vitro [Elektronische Daten] [E. I. Elueze, S. L. Croft, D. C. Warhurst] Pyronaridine, an acndine derivative, has been found effective in China for the treatment of drug-resistant falciparum malaria. The activities of pyronaridine and mepacrine were compared with those of standard antimalarial drugs in vitro against chloroquine-sensitive (CS) and chloroquine-resistant (CR) Plasmodium falciparum isolates to investigate cross resistance. The 50% inhibitory concentrations (IC50) against the resistant isolates were 2.8-fold higher than the sensitive isolates for pyronaridine (CS = 7.3 nM; CR = 20.5 nM) and 3.2-fold higher for mepacrine (CS = 13.3 nM; CR = 42.6 nM). These same isolates showed an 11-fold difference in sensitivity to chloroquine with mean 1C50 values of 21 nM for sensitive and 239 nM for resistant parasites. A significant correlation was observed between parasite sensitivity (IC50) to pyronaridine and the drugs, mepacrine, amodiaquine and chloroquine. However, the high level of activity seen with pyronaridine, even against the CR isolates, should encourage further field trials with this drug. © 1996 The British Society for Antimicrobial Chemotherapy Original articles nationallicence Elueze E. I. Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK aut Croft S. L. Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK aut Warhurst D. C. Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK aut Journal of Antimicrobial Chemotherapy Oxford University Press 37/3(1996-03), 511-518 0305-7453 37:3<511 1996 37 jac https://doi.org/10.1093/jac/37.3.511 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/37.3.511 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Elueze E. I. Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK aut NATIONALLICENCE 700 1- Croft S. L. Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK aut NATIONALLICENCE 700 1- Warhurst D. C. Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 37/3(1996-03), 511-518 0305-7453 37:3<511 1996 37 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford