caa a22 4500 397590504 CHVBK 20180308164937.0 cr unu---uuuuu 161202e199604 xx s 000 0 eng 10.1093/jac/37.4.697 doi (NATIONALLICENCE)oxford-10.1093/jac/37.4.697 In-vitro evaluation of β-lactamase inhibition by latamoxef and imipenem [Elektronische Daten] [Albert Sotto, Caroline Brunschwig, David O'Callaghan, Michel Ramuz, Jacques Jourdan] The in-vitro 50% inhibitory concentrations (IC50S) of latamoxef and imipenem against a set of plasmid-mediated β-lactamases including TEM-1, TEM-3, TEM-5 and TEM-10 were determined by an enzymatic method using nitrocefin as substrate. The IC50S of both antibiotics against extended-spectrum β-lactamases were below 0.2 mg/L. The conventional spectrum β-lactamase TEM-1 was not inhibited by either antibiotic at the highest concentration tested. Except for TEM-10 for which the IC50S of the two antibiotics were the same, imipenem showed significantly greater activity than latamoxef against TEM-3 and TEM-5. Clavulanic acid taken as a control demonstrated greater and wider inhibitory activity, but on the other hand it has no significant antibiotic activity. © 1996 The British Society for Antimicrobial Chemotherapy Original articles nationallicence Sotto Albert Laboratoire Universitaire de Thérapeutique, Service de Médecine B, Hoôital Carémeau Rue du Professeur Debré, 30900 Nimes aut Brunschwig Caroline Laboratoire Universitaire de Thérapeutique, Service de Médecine B, Hoôital Carémeau Rue du Professeur Debré, 30900 Nimes aut O'Callaghan David INSERM Unité 431, Faculté de Médecine Avenue Kennedy, 30900 Nimes, France aut Ramuz Michel INSERM Unité 431, Faculté de Médecine Avenue Kennedy, 30900 Nimes, France aut Jourdan Jacques Laboratoire Universitaire de Thérapeutique, Service de Médecine B, Hoôital Carémeau Rue du Professeur Debré, 30900 Nimes aut Journal of Antimicrobial Chemotherapy Oxford University Press 37/4(1996-04), 697-701 0305-7453 37:4<697 1996 37 jac https://doi.org/10.1093/jac/37.4.697 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/37.4.697 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sotto Albert Laboratoire Universitaire de Thérapeutique, Service de Médecine B, Hoôital Carémeau Rue du Professeur Debré, 30900 Nimes aut NATIONALLICENCE 700 1- Brunschwig Caroline Laboratoire Universitaire de Thérapeutique, Service de Médecine B, Hoôital Carémeau Rue du Professeur Debré, 30900 Nimes aut NATIONALLICENCE 700 1- O'Callaghan David INSERM Unité 431, Faculté de Médecine Avenue Kennedy, 30900 Nimes, France aut NATIONALLICENCE 700 1- Ramuz Michel INSERM Unité 431, Faculté de Médecine Avenue Kennedy, 30900 Nimes, France aut NATIONALLICENCE 700 1- Jourdan Jacques Laboratoire Universitaire de Thérapeutique, Service de Médecine B, Hoôital Carémeau Rue du Professeur Debré, 30900 Nimes aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 37/4(1996-04), 697-701 0305-7453 37:4<697 1996 37 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford