caa a22 4500 397590571 CHVBK 20180308164937.0 cr unu---uuuuu 161202e199601 xx s 000 0 eng 10.1093/jac/37.1.45 doi (NATIONALLICENCE)oxford-10.1093/jac/37.1.45 Susceptibility of Helicobacter pylori to simethicone and other non-antibiotic drugs [Elektronische Daten] [R. Ansorg, G. von Recklinghausen, E. Heintschel von Heinegg] The antifoaming agent simethicone (Lefax), the protease inhibitor gabexate mesilate (FOY), the antimycotic ketoconazole, and the hydroxyl scavangers dimethylsulphoxide (DMSO) and allopurinol were investigated for growth inhibition of Helicobacter pylori and representative strains of other bacterial species. H. pylori were selectively inhibited by 64-128 mg/L of simethicone, 64-128 mg/L gabexate mesilate, and 16-64 mg/L ketoconazole Dimethylsulphoxide and allopurinol showed no antibacterial effect at concentrations used therapeutically. It is concluded that gabexate mesilate, ketoconazole and, particularly, simethicone are candidates for treatment of H. pylori infection. © 1996 The British Society for Antimicrobial Chemotherapy Original articles nationallicence Ansorg R. Institute of Medical Microbiology, University of Essen, 45147 Essen, Germany aut von Recklinghausen G. Institute of Medical Microbiology, University of Essen, 45147 Essen, Germany aut von Heinegg E. Heintschel Institute of Medical Microbiology, University of Essen, 45147 Essen, Germany aut Journal of Antimicrobial Chemotherapy Oxford University Press 37/1(1996-01), 45-52 0305-7453 37:1<45 1996 37 jac https://doi.org/10.1093/jac/37.1.45 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/37.1.45 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ansorg R. Institute of Medical Microbiology, University of Essen, 45147 Essen, Germany aut NATIONALLICENCE 700 1- von Recklinghausen G. Institute of Medical Microbiology, University of Essen, 45147 Essen, Germany aut NATIONALLICENCE 700 1- von Heinegg E. Heintschel Institute of Medical Microbiology, University of Essen, 45147 Essen, Germany aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 37/1(1996-01), 45-52 0305-7453 37:1<45 1996 37 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford