caa a22 4500 397590644 CHVBK 20180308164937.0 cr unu---uuuuu 161202e199608 xx s 000 0 eng 10.1093/jac/38.2.301 doi (NATIONALLICENCE)oxford-10.1093/jac/38.2.301 Optimizing the timing of antimicrobial prophylaxis in surgery: an intervention study [Elektronische Daten] [Inge C. Gyssens, Irene E. J. Geerligs, Marfa G. Nannini-Bergman, Johannes T. A. Knape, Yechiel A. Hekster, Jos W. M. van der Meer] The timing of surgical antimicrobial prophylaxis was determined before and after an intervention programme of education of surgeons, anaesthetists and nurses on the subject of antimicrobial drug prophylaxis, and the subsequent implementation of new protocols of single dose prophylaxis administered within one hour before incision. This prospective study was performed in three surgical departments of a university hospital. For comparison, the timing of prophylaxis was also determined in an operating department of a community hospital. The timing improved considerably in the departments of the university hospital where the intervention was carried out: administration of the first dose within one hour before incision increased from 39% to 69% in department A and from 64% to 80% in department B. Before the intervention, seven out of 16 prophylactic doses were given after inflation of the tourniquet. After the intervention all doses of prophylactic antibiotics were administered before inflation of the tourniquet. Initially, the intervals of multidose prophylaxis varied widely. In the second review, single-dose prophylaxis increased from 21% to 78% in department A and from 31% to 85% in department B. We conclude that the intervention succeeded in improving the quality of surgical prophylaxis. © 1996 by the British Society for Antimicrobial Chemotherapy Antimicrobial practice nationallicence Gyssens Inge C. Department of General Internal Medicine, University Hospital Nijmegen The Netherlands aut Geerligs Irene E. J. Department of Clinical Pharmacy The Netherlands aut Nannini-Bergman Marfa G. Department of Clinical Pharmacy The Netherlands aut Knape Johannes T. A. Department of Anaesthesiology, University Hospital Nijmegen The Netherlands aut Hekster Yechiel A. Department of Clinical Pharmacy The Netherlands aut van der Meer Jos W. M. Department of General Internal Medicine, University Hospital Nijmegen The Netherlands aut Journal of Antimicrobial Chemotherapy Oxford University Press 38/2(1996-08), 301-308 0305-7453 38:2<301 1996 38 jac https://doi.org/10.1093/jac/38.2.301 text/html Onlinezugriff via DOI 1 other jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/38.2.301 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gyssens Inge C. Department of General Internal Medicine, University Hospital Nijmegen The Netherlands aut NATIONALLICENCE 700 1- Geerligs Irene E. J. Department of Clinical Pharmacy The Netherlands aut NATIONALLICENCE 700 1- Nannini-Bergman Marfa G. Department of Clinical Pharmacy The Netherlands aut NATIONALLICENCE 700 1- Knape Johannes T. A. Department of Anaesthesiology, University Hospital Nijmegen The Netherlands aut NATIONALLICENCE 700 1- Hekster Yechiel A. Department of Clinical Pharmacy The Netherlands aut NATIONALLICENCE 700 1- van der Meer Jos W. M. Department of General Internal Medicine, University Hospital Nijmegen The Netherlands aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 38/2(1996-08), 301-308 0305-7453 38:2<301 1996 38 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford