caa a22 4500 397590695 CHVBK 20180308164937.0 cr unu---uuuuu 161202e199610 xx s 000 0 eng 10.1093/jac/38.4.679 doi (NATIONALLICENCE)oxford-10.1093/jac/38.4.679 Analysis of oral antibiotic treatment that failed to prevent the development of Haemophilus influenzae meningitis: consequences on mortality [Elektronische Daten] [H. Dabernat, A. Scheimberg, J. Astruc] One hundred and four children suffering from Haemophilus influenzae meningitis were studied in a multi-centre study in France between October 1991 and June 1993. The clinical and bacteriological findings were similar to those usually found in this condition. Fifty three per cent of the H. influenzae strains cultured produced β-lactamase and 98% were of type b. Forty-six children who had been prescribed oral antibiotics before hospitalisation were analysed in this study. This analysis took into account the nature of the antibiotic and whether it was prescribed as the treatment of first or second intention. Treatment failures, defined according to pre-established criteria, were found to be independent of whether or not the incriminated strain was β-lactamase producing and whether or not it was sensitive in vitro to the antibiotic prescribed. None of the 46 children who had received pre-hospital oral antibiotics died while three of the 58 who had not received pre-hospital oral antibiotics died. However, it is difficult to establish in our study a clear relationship between the reduction of mortality and previous oral antibiotic treatment in bacteriologically proven cases of H. influenzae meningitis. © 1995 The British Society for Antimicrobial Chemotherapy Original articles nationallicence Dabernat H. Centre Hospitaller Universitaire de Purpan Service de Bactériologie, 31059 Toulouse aut Scheimberg A. Laboratoire Bellon 159 avenue Achille Peretti, 92201 Neuilly sur Seine aut Astruc J. Hôpital Arnaud de Villeneuve Pédiatrie III, 371, av du doyen G. Giraud 34295 Montpellier Cedex 5, France aut Journal of Antimicrobial Chemotherapy Oxford University Press 38/4(1996-10), 679-689 0305-7453 38:4<679 1996 38 jac https://doi.org/10.1093/jac/38.4.679 text/html Onlinezugriff via DOI 1 other jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/38.4.679 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dabernat H. Centre Hospitaller Universitaire de Purpan Service de Bactériologie, 31059 Toulouse aut NATIONALLICENCE 700 1- Scheimberg A. Laboratoire Bellon 159 avenue Achille Peretti, 92201 Neuilly sur Seine aut NATIONALLICENCE 700 1- Astruc J. Hôpital Arnaud de Villeneuve Pédiatrie III, 371, av du doyen G. Giraud 34295 Montpellier Cedex 5, France aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 38/4(1996-10), 679-689 0305-7453 38:4<679 1996 38 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford