caa a22 4500 397590814 CHVBK 20180308164938.0 cr unu---uuuuu 161202e199605 xx s 000 0 eng 10.1093/jac/37.5.855 doi (NATIONALLICENCE)oxford-10.1093/jac/37.5.855 Courvalin P. Department of Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0116, USA The Garrod Lecture Evasion of antibiotic action by bacteria [Elektronische Daten] [P. Courvalin] Antibiotics have reduced the mortality from infectious diseases but not the prevalence of these diseases. Use, and often abuse, of antimicrobial agents encourages the evolution of bacteria toward resistance, often resulting in therapeutic failure. This evolution is due to the emergence of ‘new' resistance mechanisms and to the spread of well-characterized mechanisms of resistance to the majority of bacterial species. Bacterial resistance can be intrinsic or acquired. Intrinsic resistance is species or genus specific and delineates the spectrum of activity of the antibiotic. Acquired resistance is present in only certain strains of a species or of a genus. The latter results from mutation in a gene located in the host chromosome or a plasmid or from acquisition of new genetic information by a bacterium, mainly by conjugation or transformation. In this review, recent developments in the understanding of biochemical mechanisms and the genetics of resistance is considered for the clinically important antibiotic families. © 1996 The British Society for Antimicrobial Chemotherapy The Garrod Lecture nationallicence Journal of Antimicrobial Chemotherapy Oxford University Press 37/5(1996-05), 855-869 0305-7453 37:5<855 1996 37 jac https://doi.org/10.1093/jac/37.5.855 text/html Onlinezugriff via DOI 1 other jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/37.5.855 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Courvalin P. Department of Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0116, USA NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 37/5(1996-05), 855-869 0305-7453 37:5<855 1996 37 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford