caa a22 4500 397590830 CHVBK 20180308164938.0 cr unu---uuuuu 161202e199612 xx s 000 0 eng 10.1093/jac/38.6.1091 doi (NATIONALLICENCE)oxford-10.1093/jac/38.6.1091 Bolus or infusion teicoplanin for intravascular catheter associated infections in immunocompromised patients? [Elektronische Daten] [B. E. Ley, N. Jalil, J. McIntosh, A. Smarf, M. Wilson, A. B. M. Foot, M. R. Millar] An unexpected low efficacy of teicoplanin in the treatment of coagulase negative staphylococcal (CNS) infections on a regional Bone Marrow Transplant (BMT) Unit led to a retrospective study. CNS infections treated with gylcopeptides in BMT patients with in-dwelling central venous lines between May 1990 and May 1995 were reviewed. Efficacy rates of 50% for teicoplanin compared with 80% for vancomycin despite comparable antibiotic susceptibility. Glycopeptides have bactericidal action which is time dependent. Teicoplanin was administered by bolus injection during the study period and it is suggested that this observed difference in efficacy is caused by the short duration of exposure of luminal bacteria. © 1996 by the British Society for Antimicrobial Chemotherapy Brief reports nationallicence Ley B. E. Department of Paediatric Oncology, Bristol Royal Hospital for Sick Children St Michaels Hill, Bristol BS2 8BJ aut Jalil N. Department of Microbiology, Bristol Royal Infirmary Bristol aut McIntosh J. Department of Pathology & Microbiology, University of Bristol Bristol, UK aut Smarf A. Department of Pathology & Microbiology, University of Bristol Bristol, UK aut Wilson M. Department of Microbiology, Bristol Royal Infirmary Bristol aut Foot A. B. M. Department of Paediatric Oncology, Bristol Royal Hospital for Sick Children St Michaels Hill, Bristol BS2 8BJ aut Millar M. R. Department of Pathology & Microbiology, University of Bristol Bristol, UK aut Journal of Antimicrobial Chemotherapy Oxford University Press 38/6(1996-12), 1091-1095 0305-7453 38:6<1091 1996 38 jac https://doi.org/10.1093/jac/38.6.1091 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/38.6.1091 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ley B. E. Department of Paediatric Oncology, Bristol Royal Hospital for Sick Children St Michaels Hill, Bristol BS2 8BJ aut NATIONALLICENCE 700 1- Jalil N. Department of Microbiology, Bristol Royal Infirmary Bristol aut NATIONALLICENCE 700 1- McIntosh J. Department of Pathology & Microbiology, University of Bristol Bristol, UK aut NATIONALLICENCE 700 1- Smarf A. Department of Pathology & Microbiology, University of Bristol Bristol, UK aut NATIONALLICENCE 700 1- Wilson M. Department of Microbiology, Bristol Royal Infirmary Bristol aut NATIONALLICENCE 700 1- Foot A. B. M. Department of Paediatric Oncology, Bristol Royal Hospital for Sick Children St Michaels Hill, Bristol BS2 8BJ aut NATIONALLICENCE 700 1- Millar M. R. Department of Pathology & Microbiology, University of Bristol Bristol, UK aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 38/6(1996-12), 1091-1095 0305-7453 38:6<1091 1996 38 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford