caa a22 4500 397590903 CHVBK 20180308164938.0 cr unu---uuuuu 161202e199607 xx s 000 0 eng 10.1093/jac/38.suppl_A.71 doi (NATIONALLICENCE)oxford-10.1093/jac/38.suppl_A.71 Antimicrobial resistance among lower respiratory tract isolates of Streptococcus pneumoniae: results of a 1992-93 Western Europe and USA collaborative surveillance study [Elektronische Daten] [F. W. Goldstein, J. F. Acar] One thousand, eight hundred and fifty-six Streptococcus pneumoniae strains, collected in 1992 and 1993 from 15 centres in Western Europe and USA were tested for susceptibility to 16 antibiotics. The overall resistance to penicillin was 23% (range 6-54%), with the highest prevalences in Madrid, Barcelona, Toulouse and Cleveland. Seven centres reported low-level penicillin resistance only. Amoxycillin was more active than ceftriaxone against strains with intermediate resistance to penicillin, and at least four-fold more active than cefuroxime; cefaclor and cefixime had poor activity. Against penicillin-resistant strains, ceftriaxone was slightly more active than amoxycillin, cefuroxime exhibited borderline activity and cefixime and cefaclor were inactive. Ten strains fully susceptible to penicillin had MICs of ceftriaxone ≥ 0.1 mg/L; this may represent a first step towards the development of cephalosporin resistance. With the exception of fluoroquinolones, resistance to non-β-lactam antibiotics (chloramphenicol, doxycycline, co-trimoxazole, ery-thromycin, clarithromycin and azithromycin) was considerably higher in penicillin-resistant strains compared with penicillin-susceptible isolates. Ery-thromycin-resistant isolates were also resistant to the other macrolides tested. © 1996 The British Society for Antimicrobial Chemotherapy Articles nationallicence Goldstein F. W. Laboratoire de Microbiologie Medicale Fondation Hopital Saint-Joseph 185 rue Raymond Losserand, 75674 Paris Cedex 14, France aut Acar J. F. Laboratoire de Microbiologie Medicale Fondation Hopital Saint-Joseph 185 rue Raymond Losserand, 75674 Paris Cedex 14, France aut Journal of Antimicrobial Chemotherapy Oxford University Press 38(1996-07), 71-84 0305-7453 38<71 1996 38 jac https://doi.org/10.1093/jac/38.suppl_A.71 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/38.suppl_A.71 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Goldstein F. W. Laboratoire de Microbiologie Medicale Fondation Hopital Saint-Joseph 185 rue Raymond Losserand, 75674 Paris Cedex 14, France aut NATIONALLICENCE 700 1- Acar J. F. Laboratoire de Microbiologie Medicale Fondation Hopital Saint-Joseph 185 rue Raymond Losserand, 75674 Paris Cedex 14, France aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 38(1996-07), 71-84 0305-7453 38<71 1996 38 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford