caa a22 4500 397590989 CHVBK 20180308164938.0 cr unu---uuuuu 161202e199603 xx s 000 0 eng 10.1093/jac/37.3.605 doi (NATIONALLICENCE)oxford-10.1093/jac/37.3.605 Penicillin-binding protein 5 as an inhibitory target of cefozopran in Enterococcus faecalis [Elektronische Daten] [Noboru Tsuchimori, Kenji Okonogi] The concentration of cefozopran which inhibits binding of [14C]benzylpenicillin to penicillin-binding protein (PBP) 5 of Enterococcus faecalis TN2005 by 50% was 11 mg/L, and its MIC was 12.5 mg/L. Ceftazidime and cefmenoxime, which were inactive at 100 mg/L, showed no affinity for PBP 5 at this concentration. Ampicillin, benzylpenicillin and imipenem showed higher affinity for PBPs 3/4 and PBP 5 than cefozopran, and their MICs were lower than that of cefozopran. No correlation between MICs of the test compounds and the affinity for PBP 1, 2 or 6 was found. These results suggest that cefozopran exhibits antimicrobial activity against E. faecalis TN2005 by binding to PBP 5. © 1996 The British Society for Antimicrobial Chemotherapy Brief reports nationallicence Tsuchimori Noboru Pharmaceutical Research Laboratories III, Takeda Chemical Industries Ltd, 2-17-85 Jusohonmachi, Yodogawa-ku, Osaka 532, Japan aut Okonogi Kenji Pharmaceutical Research Laboratories III, Takeda Chemical Industries Ltd, 2-17-85 Jusohonmachi, Yodogawa-ku, Osaka 532, Japan aut Journal of Antimicrobial Chemotherapy Oxford University Press 37/3(1996-03), 605-609 0305-7453 37:3<605 1996 37 jac https://doi.org/10.1093/jac/37.3.605 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/37.3.605 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tsuchimori Noboru Pharmaceutical Research Laboratories III, Takeda Chemical Industries Ltd, 2-17-85 Jusohonmachi, Yodogawa-ku, Osaka 532, Japan aut NATIONALLICENCE 700 1- Okonogi Kenji Pharmaceutical Research Laboratories III, Takeda Chemical Industries Ltd, 2-17-85 Jusohonmachi, Yodogawa-ku, Osaka 532, Japan aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 37/3(1996-03), 605-609 0305-7453 37:3<605 1996 37 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford