caa a22 4500 39759108X CHVBK 20180308164938.0 cr unu---uuuuu 161202e199606 xx s 000 0 eng 10.1093/jac/37.6.1091 doi (NATIONALLICENCE)oxford-10.1093/jac/37.6.1091 Effect of growth conditions on antimicrobial activity of DU-6859a and its bactericidal activity determined by the killing curve method [Elektronische Daten] [Mayumi Tanaka, Kazuki Hoshino, Masato Hohmura, Hiroko Ishida, Akihiro Kitamura, Kenichi Sato, Isao Hayakawa, Takeshi Nishino] The effect of growth conditions on the antibacterial activity of DU-6859a against Staphylococcus auerus, Escherichia coli, and Pseudomonas aeruginosa was compared with those of levofloxacin, sparfloxacin, and ciprofloxacin. This activity was not affected by different media, inoculum size or the addition of human serum, but was decreased under acidic conditions, in human urine, and in the presence of magnesium and ferrous ion, as were the other quinolones tested. Time-kill curve studies demonstrated the bactericidal action of DU-6859a against S. aureus, Streptococcus pneumoniae, E. coli, and P. aeruginosa. Morphological alteration of these bacteria after exposure to DU-6859a also demonstrated its bactericidal activity. The frequency of spontaneous resistance to DU-6859a was less than or equal to those of the reference drugs. © 1996 The British Society for Antimicrobial Chemotherapy Original articles nationallicence Tanaka Mayumi New Product Research Laboratories I, Daiichi Pharmaceutical Co, Ltd. 16-13, Kita-kasai 1-chome, Edogawa-ku, Tokyo 134, Japan aut Hoshino Kazuki New Product Research Laboratories I, Daiichi Pharmaceutical Co, Ltd. 16-13, Kita-kasai 1-chome, Edogawa-ku, Tokyo 134, Japan aut Hohmura Masato New Product Research Laboratories I, Daiichi Pharmaceutical Co, Ltd. 16-13, Kita-kasai 1-chome, Edogawa-ku, Tokyo 134, Japan aut Ishida Hiroko New Product Research Laboratories I, Daiichi Pharmaceutical Co, Ltd. 16-13, Kita-kasai 1-chome, Edogawa-ku, Tokyo 134, Japan aut Kitamura Akihiro New Product Research Laboratories I, Daiichi Pharmaceutical Co, Ltd. 16-13, Kita-kasai 1-chome, Edogawa-ku, Tokyo 134, Japan aut Sato Kenichi New Product Research Laboratories I, Daiichi Pharmaceutical Co, Ltd. 16-13, Kita-kasai 1-chome, Edogawa-ku, Tokyo 134, Japan aut Hayakawa Isao New Product Research Laboratories I, Daiichi Pharmaceutical Co, Ltd. 16-13, Kita-kasai 1-chome, Edogawa-ku, Tokyo 134, Japan aut Nishino Takeshi Department of Microbiology, Kyoto Pharmaceutical University 5 Nakauchicho, Misasagi, Yamashina-ku, Kyoto 607, Japan aut Journal of Antimicrobial Chemotherapy Oxford University Press 37/6(1996-06), 1091-1102 0305-7453 37:6<1091 1996 37 jac https://doi.org/10.1093/jac/37.6.1091 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/37.6.1091 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tanaka Mayumi New Product Research Laboratories I, Daiichi Pharmaceutical Co, Ltd. 16-13, Kita-kasai 1-chome, Edogawa-ku, Tokyo 134, Japan aut NATIONALLICENCE 700 1- Hoshino Kazuki New Product Research Laboratories I, Daiichi Pharmaceutical Co, Ltd. 16-13, Kita-kasai 1-chome, Edogawa-ku, Tokyo 134, Japan aut NATIONALLICENCE 700 1- Hohmura Masato New Product Research Laboratories I, Daiichi Pharmaceutical Co, Ltd. 16-13, Kita-kasai 1-chome, Edogawa-ku, Tokyo 134, Japan aut NATIONALLICENCE 700 1- Ishida Hiroko New Product Research Laboratories I, Daiichi Pharmaceutical Co, Ltd. 16-13, Kita-kasai 1-chome, Edogawa-ku, Tokyo 134, Japan aut NATIONALLICENCE 700 1- Kitamura Akihiro New Product Research Laboratories I, Daiichi Pharmaceutical Co, Ltd. 16-13, Kita-kasai 1-chome, Edogawa-ku, Tokyo 134, Japan aut NATIONALLICENCE 700 1- Sato Kenichi New Product Research Laboratories I, Daiichi Pharmaceutical Co, Ltd. 16-13, Kita-kasai 1-chome, Edogawa-ku, Tokyo 134, Japan aut NATIONALLICENCE 700 1- Hayakawa Isao New Product Research Laboratories I, Daiichi Pharmaceutical Co, Ltd. 16-13, Kita-kasai 1-chome, Edogawa-ku, Tokyo 134, Japan aut NATIONALLICENCE 700 1- Nishino Takeshi Department of Microbiology, Kyoto Pharmaceutical University 5 Nakauchicho, Misasagi, Yamashina-ku, Kyoto 607, Japan aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 37/6(1996-06), 1091-1102 0305-7453 37:6<1091 1996 37 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford