caa a22 4500 397591101 CHVBK 20180308164938.0 cr unu---uuuuu 161202e199610 xx s 000 0 eng 10.1093/jac/38.4.605 doi (NATIONALLICENCE)oxford-10.1093/jac/38.4.605 The mode of antibacterial action of the novel agent ZM240304 (D-arabino-2,3,4-tris(4-chlorobenzyl) pentane-l,5-diamine) [Elektronische Daten] [Keith Barrett-Bee, Lorraine Newboult, John Stawpert] ZM240304 is an example of a new class of antibacterial agents that is active against experimental infections in animals. The compound was demonstrated to be a membrane-active compound that disrupted the outer membrane of Gram-negative organisms and allowed the leakage of periplasmic enzymes. Respiration was inhibited and cellular ATP levels were reduced, leading to cell death. The ability of the bacteria to take up small molecules such as amino acids and sugars was inhibited, probably by interference with inner membrane function. © 1995 The British Society for Antimicrobial Chemotherapy Original articles nationallicence Barrett-Bee Keith Department of Infection, Zeneca Pharmaceuticals, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK aut Newboult Lorraine Department of Infection, Zeneca Pharmaceuticals, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK aut Stawpert John Department of Infection, Zeneca Pharmaceuticals, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK aut Journal of Antimicrobial Chemotherapy Oxford University Press 38/4(1996-10), 605-614 0305-7453 38:4<605 1996 38 jac https://doi.org/10.1093/jac/38.4.605 text/html Onlinezugriff via DOI 1 other jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/38.4.605 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Barrett-Bee Keith Department of Infection, Zeneca Pharmaceuticals, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK aut NATIONALLICENCE 700 1- Newboult Lorraine Department of Infection, Zeneca Pharmaceuticals, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK aut NATIONALLICENCE 700 1- Stawpert John Department of Infection, Zeneca Pharmaceuticals, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 38/4(1996-10), 605-614 0305-7453 38:4<605 1996 38 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford