caa a22 4500 397591160 CHVBK 20180308164939.0 cr unu---uuuuu 161202e199604 xx s 000 0 eng 10.1093/jac/37.4.803 doi (NATIONALLICENCE)oxford-10.1093/jac/37.4.803 Comparative in-vitro activity of CP-99219, a new quinolone, against respiratory pathogens [Elektronische Daten] [A. M. Sefton, J. P. Maskell, A. C. Seymour, M. Minassian, J. D. Williams] The comparative in-vitro activity of CP-99219, a new quinolone, against Haemophilus influenzae (150 isolates), Moraxella catarrhalis (100), Streptococcus pneumoniae (80) and Group A β-haemolytic streptococci (40) was determined using an agar dilution technique. CP-99219 was the most active compound tested against M. catarrhalis (MIC50=0.015 mg/L, MIC90=0.03 mg/L). Ceftriaxone, CP-99219 and ciprofloxacin were the three most active agents tested against H. influenzae. CP-99219 showed good activity, 16-fold greater than that of ciprofloxacin, against S. pneumoniae (MIC50=0.12 mg/L; MIC90=0.25 mg/L) and was also active against Group A streptococci. Clinical studies regarding the use of CP-99219 in respiratory tract infections seem indicated. © 1996 The British Society for Antimicrobial Chemotherapy Brief reports nationallicence Sefton A. M. Department of Medical Microbiology, The London Hospital Medical College, London, El 2AD, UK aut Maskell J. P. Department of Medical Microbiology, The London Hospital Medical College, London, El 2AD, UK aut Seymour A. C. Department of Medical Microbiology, The London Hospital Medical College, London, El 2AD, UK aut Minassian M. Department of Medical Microbiology, The London Hospital Medical College, London, El 2AD, UK aut Williams J. D. Department of Medical Microbiology, The London Hospital Medical College, London, El 2AD, UK aut Journal of Antimicrobial Chemotherapy Oxford University Press 37/4(1996-04), 803-808 0305-7453 37:4<803 1996 37 jac https://doi.org/10.1093/jac/37.4.803 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/37.4.803 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sefton A. M. Department of Medical Microbiology, The London Hospital Medical College, London, El 2AD, UK aut NATIONALLICENCE 700 1- Maskell J. P. Department of Medical Microbiology, The London Hospital Medical College, London, El 2AD, UK aut NATIONALLICENCE 700 1- Seymour A. C. Department of Medical Microbiology, The London Hospital Medical College, London, El 2AD, UK aut NATIONALLICENCE 700 1- Minassian M. Department of Medical Microbiology, The London Hospital Medical College, London, El 2AD, UK aut NATIONALLICENCE 700 1- Williams J. D. Department of Medical Microbiology, The London Hospital Medical College, London, El 2AD, UK aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 37/4(1996-04), 803-808 0305-7453 37:4<803 1996 37 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford