caa a22 4500 397591209 CHVBK 20180308164939.0 cr unu---uuuuu 161202e199610 xx s 000 0 eng 10.1093/jac/38.4.627 doi (NATIONALLICENCE)oxford-10.1093/jac/38.4.627 A multinational European survey on the in-vitro activity of rufloxacin and other comparative antibiotics on respiratory and urinary bacterial pathogens [Elektronische Daten] [G. C. Schito, J. F. Acar, A. Bauernfeind, J. Duval, R. G. Finch, J. Focht, G. Nicoletti, I. Phillips, G. Pratts, F. Soriano, B. Wiedeman, R. Wise] The antibacterial activity of rufloxacin was confirmed against a large number of respiratory and urinary tract pathogens collected in five European countries. In terms of both MIC90 values and percentages of susceptible isolates found, this new quinolone showed useful in-vitro activity against Mycoplasma catarrhalis, Haemophilus influenzae and Klebsiella pneumoniae, with a large proportion of Staphylococcus aureus also covered, while, as expected Streptococcus pneumoniae and Streptococcus pyogenes were not included in its antibacterial spectrum. Rufloxacin was comparable with the other antibiotics against these pathogens with the exception of streptococci. Against these microorganisms, β-lactams were the most active agents. Against the urinary pathogens the in-vitro activity of rufloxacin is similar to that of norfloxacin although this latter drug is more active in terms of MIC90 values and in percentages of strains inhibited. In many cases more isolates were susceptible to the remaining comparator agents than to rufloxacin. However, there were no significant differences between the numbers of microorganisms inhibited by the various drugs and rufloxacin. The findings of this survey do not seem to modify the general picture which emerged in previous studies and further confirms its useful spectrum in different geographic settings. © 1995 The British Society for Antimicrobial Chemotherapy Original articles nationallicence Schito G. C. Institutes of Microbiology, Universitiy of Genoa Italy aut Acar J. F. Institutes of Microbiology, Service de Microbiologie Medicale, Hospital Saint Joseph Paris aut Bauernfeind A. Department of Microbioloy, Max von Pettenkofer-Institut, Universitat Munchen aut Duval J. Institutes of Microbiology, Service de Bacteriologie-Virologie-Hygiene, Hospital Henri Mondor Creteil, France aut Finch R. G. Department of Microbial Diseases, University of Nottingham London aut Focht J. Bioscientia, Institut für Laboruntesuchungen Moers aut Nicoletti G. Institutes of Microbiology, Universitiy of Catania Italy aut Phillips I. department of Microbiology, St. Thomas Hospital London aut Pratts G. Microbiology Department, Hospital Santa Creu i Sant Pau Barcelona aut Soriano F. Departamento de Microbiologia Medica, Fundaci ón Jiménez Diaz Madrid, Spain aut Wiedeman B. Pharmazeutische Mikrobiologie, Universität Bonn Germany aut Wise R. Department of Medical Microbiology, Dudley Road Hospital Birmingham, UK aut Journal of Antimicrobial Chemotherapy Oxford University Press 38/4(1996-10), 627-639 0305-7453 38:4<627 1996 38 jac https://doi.org/10.1093/jac/38.4.627 text/html Onlinezugriff via DOI 1 other jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/38.4.627 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schito G. C. Institutes of Microbiology, Universitiy of Genoa Italy aut NATIONALLICENCE 700 1- Acar J. F. Institutes of Microbiology, Service de Microbiologie Medicale, Hospital Saint Joseph Paris aut NATIONALLICENCE 700 1- Bauernfeind A. Department of Microbioloy, Max von Pettenkofer-Institut, Universitat Munchen aut NATIONALLICENCE 700 1- Duval J. Institutes of Microbiology, Service de Bacteriologie-Virologie-Hygiene, Hospital Henri Mondor Creteil, France aut NATIONALLICENCE 700 1- Finch R. G. Department of Microbial Diseases, University of Nottingham London aut NATIONALLICENCE 700 1- Focht J. Bioscientia, Institut für Laboruntesuchungen Moers aut NATIONALLICENCE 700 1- Nicoletti G. Institutes of Microbiology, Universitiy of Catania Italy aut NATIONALLICENCE 700 1- Phillips I. department of Microbiology, St. Thomas Hospital London aut NATIONALLICENCE 700 1- Pratts G. Microbiology Department, Hospital Santa Creu i Sant Pau Barcelona aut NATIONALLICENCE 700 1- Soriano F. Departamento de Microbiologia Medica, Fundaci ón Jiménez Diaz Madrid, Spain aut NATIONALLICENCE 700 1- Wiedeman B. Pharmazeutische Mikrobiologie, Universität Bonn Germany aut NATIONALLICENCE 700 1- Wise R. Department of Medical Microbiology, Dudley Road Hospital Birmingham, UK aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 38/4(1996-10), 627-639 0305-7453 38:4<627 1996 38 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford