caa a22 4500 397591217 CHVBK 20180308164939.0 cr unu---uuuuu 161202e199606 xx s 000 0 eng 10.1093/jac/37.suppl_C.133 doi (NATIONALLICENCE)oxford-10.1093/jac/37.suppl_C.133 Nahata M. Colleges of Pharmacy and Medicine, Ohio State University, 500 West 12th Avenue, Columbus, OH 43210, USA Drug interactions with azithromycin and the macrolides: an overview [Elektronische Daten] [M. Nahata] Evidence interactions between individual macrolides and a number of pharmacologically active compounds that are frequently co-administered to patients with bacterial infections is reviewed. Theophylline is strongly associated with erythromycin interaction; clarithromycin may also interact with this drug. Azithromycin, spiramycin and rokitamycin, however, do not appear to have any effect on theophylline pharmacokinetics. The other therapeutic agents considered are cyclosporin, the antiepileptics, carbamazepine and phcnytoin, terfenadine, warfarin, oral contraceptives, agents used in the management of gastritis and peptic ulcer and zidovudine. With the exception of interaction with antacids, there is no evidence that azithromycin, unlike most other macrolides, interacts with any of these agents to produce clinically significant adverse effects. The explanation for this variation appears to be azithromycin's inability to induce and bind to the cytochrome P450 IIIA enzyme system. © 1996 The British Society for Antimicrobial Chemotherapy Articles nationallicence Journal of Antimicrobial Chemotherapy Oxford University Press 37(1996-06), 133-142 0305-7453 37<133 1996 37 jac https://doi.org/10.1093/jac/37.suppl_C.133 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/37.suppl_C.133 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Nahata M. Colleges of Pharmacy and Medicine, Ohio State University, 500 West 12th Avenue, Columbus, OH 43210, USA NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 37(1996-06), 133-142 0305-7453 37<133 1996 37 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford