caa a22 4500 397591284 CHVBK 20180308164939.0 cr unu---uuuuu 161202e199608 xx s 000 0 eng 10.1093/jac/38.2.227 doi (NATIONALLICENCE)oxford-10.1093/jac/38.2.227 Correlation of in-vitro activity and pharmacokinetic parameters with in-vivo effect of amoxycillin, co-amoxiclav and cefotaxime in a murine model of pneumococcal pneumonia [Elektronische Daten] [F. Soriano, C. Ponte, E. Nieto, A. Parra] In an attempt to determine the susceptibility breakpoints for amoxycillin, co-amoxiclav and cefotaxime in pneumocoaral pneumonia, a neutropenic mouse mdel was established and tested with two strains having different susceptibility to penicillins and cefotaxime. With a penicillin-sensitive strain (MIC/MBC = 0.01/0.01 mg/L) the minimum dosage tested achieving significant cure was 2 mg/kg for amoxycillin, co-amoxiclav and cefotaxime. For the penicillininsensitive strain (MIC/MBC = 1/2 mg/L), the minimum dosage tested giving significant cure was 50 mg/kg for amoxycillin and co-amoxiclav but 100 mg/kg for cefotaxime. Our results support the belief that MICs of amoxycillin, co-amoxiclav and cefotaxime for pneumococcal strains of ≤ 0.5 or ≤ 1 mg/L can be considered as clinically relevant susceptibility breakpoints. © 1996 by the British Society for Antimicrobial Chemotherapy Original articles nationallicence Soriano F. Department of Medical Microbiology, Fundación Jiménez Díaz, Avenida de Reyes Católicos 2, 28040 Madrid, Spain aut Ponte C. Department of Medical Microbiology, Fundación Jiménez Díaz, Avenida de Reyes Católicos 2, 28040 Madrid, Spain aut Nieto E. Department of Medical Microbiology, Fundación Jiménez Díaz, Avenida de Reyes Católicos 2, 28040 Madrid, Spain aut Parra A. Department of Medical Microbiology, Fundación Jiménez Díaz, Avenida de Reyes Católicos 2, 28040 Madrid, Spain aut Journal of Antimicrobial Chemotherapy Oxford University Press 38/2(1996-08), 227-236 0305-7453 38:2<227 1996 38 jac https://doi.org/10.1093/jac/38.2.227 text/html Onlinezugriff via DOI 1 other jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/38.2.227 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Soriano F. Department of Medical Microbiology, Fundación Jiménez Díaz, Avenida de Reyes Católicos 2, 28040 Madrid, Spain aut NATIONALLICENCE 700 1- Ponte C. Department of Medical Microbiology, Fundación Jiménez Díaz, Avenida de Reyes Católicos 2, 28040 Madrid, Spain aut NATIONALLICENCE 700 1- Nieto E. Department of Medical Microbiology, Fundación Jiménez Díaz, Avenida de Reyes Católicos 2, 28040 Madrid, Spain aut NATIONALLICENCE 700 1- Parra A. Department of Medical Microbiology, Fundación Jiménez Díaz, Avenida de Reyes Católicos 2, 28040 Madrid, Spain aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 38/2(1996-08), 227-236 0305-7453 38:2<227 1996 38 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford