caa a22 4500 397591446 CHVBK 20180308164939.0 cr unu---uuuuu 161202e199602 xx s 000 0 eng 10.1093/jac/37.2.265 doi (NATIONALLICENCE)oxford-10.1093/jac/37.2.265 Antifungal susceptibility testing using the E test: comparison with the broth macrodilution technique [Elektronische Daten] [Sharon C. A. Chen, Maryann L. O'Donnell, Suzannah Gordon, Gwendolyn L. Gilbert] The National Committee for Clinical Laboratory Standards reference broth macrodilution method for antifungal susceptibility testing was compared with the E test by testing 86 clinical isolates of Candida spp. and Cryptococcus neoformans. The MIC agreement rates for the two methods for Candida spp. were 73-89% within ± 1 doubling dilution and 87-100% within ±2 dilutions. For C. neoformans, agreement within±1 dilution was>70% for all the agents tested except fluconazole for which agreement was 35%. Our data support the further evaluation of the E test as an alternative method for antifungal susceptibility testing. However, E test MICs of fluconazole for C. neoformans, particularly C. neoformans var. gattii should be interpreted with caution, as falsely elevated MICs may occur. © 1996 The British Society for Antimicrobial Chemotherapy Original articles nationallicence Chen Sharon C. A. Department of Clinical Microbiology, Centre for Infectious Diseases and Microbiology, Westmead Hospital, Hawkesbury Road, Westmead, New South Wales 2145, Australia aut O'Donnell Maryann L. Department of Clinical Microbiology, Centre for Infectious Diseases and Microbiology, Westmead Hospital, Hawkesbury Road, Westmead, New South Wales 2145, Australia aut Gordon Suzannah Department of Clinical Microbiology, Centre for Infectious Diseases and Microbiology, Westmead Hospital, Hawkesbury Road, Westmead, New South Wales 2145, Australia aut Gilbert Gwendolyn L. Department of Clinical Microbiology, Centre for Infectious Diseases and Microbiology, Westmead Hospital, Hawkesbury Road, Westmead, New South Wales 2145, Australia aut Journal of Antimicrobial Chemotherapy Oxford University Press 37/2(1996-02), 265-273 0305-7453 37:2<265 1996 37 jac https://doi.org/10.1093/jac/37.2.265 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/37.2.265 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chen Sharon C. A. Department of Clinical Microbiology, Centre for Infectious Diseases and Microbiology, Westmead Hospital, Hawkesbury Road, Westmead, New South Wales 2145, Australia aut NATIONALLICENCE 700 1- O'Donnell Maryann L. Department of Clinical Microbiology, Centre for Infectious Diseases and Microbiology, Westmead Hospital, Hawkesbury Road, Westmead, New South Wales 2145, Australia aut NATIONALLICENCE 700 1- Gordon Suzannah Department of Clinical Microbiology, Centre for Infectious Diseases and Microbiology, Westmead Hospital, Hawkesbury Road, Westmead, New South Wales 2145, Australia aut NATIONALLICENCE 700 1- Gilbert Gwendolyn L. Department of Clinical Microbiology, Centre for Infectious Diseases and Microbiology, Westmead Hospital, Hawkesbury Road, Westmead, New South Wales 2145, Australia aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 37/2(1996-02), 265-273 0305-7453 37:2<265 1996 37 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford